CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury.
CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury.
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DOI：
10.1517/17425255.1.4.671
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发表时间：
2005-12-01
影响因子：
4.3
通讯作者：
Cederbaum, Arthur I
中科院分区：
文献类型：
--
作者：
Jimenez-Lopez, Jose M;Cederbaum, Arthur I
乙醇诱导的氧化应激在乙醇引起肝损伤的机制中起着重要作用。许多途径有助于乙醇如何诱导氧化应激状态。一个中心途径似乎是乙醇诱导CYP2E1形式的细胞色素P450酶。CYP2E1之所以令人感兴趣，是因为它代谢和激活许多毒理学底物，包括乙醇，以产生更具反应性的产物。CYP2E1的水平在多种生理和病理生理条件下升高。CYP2E1是一种有效的活性氧生成剂。本文综述了CYP2E1的一些生化和毒理学特性，并简要介绍了使用HepG2细胞系在评估CYP2E1的行动。未来的方向，这可能有助于更好地了解CYP2E1的行动和它在酒精性肝损伤中的作用，建议。
Ethanol-induced oxidative stress plays a major role in the mechanisms by which ethanol causes liver injury. Many pathways contribute to how ethanol induces a state of oxidative stress. One central pathway appears to be the induction, by ethanol, of the CYP2E1 form of cytochrome P450 enzymes. CYP2E1 is of interest because it metabolises and activates many toxicological substrates, including ethanol, to more reactive products. Levels of CYP2E1 are elevated under a variety of physiological and pathophysiological conditions. CYP2E1 is an effective generator of reactive oxygen species. This review summarises some of the biochemical and toxicological properties of CYP2E1, and briefly describes the use of HepG2 cell lines in assessing the actions of CYP2E1. Future directions, which may help to better understand the actions of CYP2E1 and its role in alcoholic liver injury, are suggested.