Beneficial effect of zinc supplementation on biomechanical properties of femoral distal end and femoral diaphysis of male rats chronically exposed to cadmium
Beneficial effect of zinc supplementation on biomechanical properties of femoral distal end and femoral diaphysis of male rats chronically exposed to cadmium
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DOI：
10.1016/j.cbi.2007.11.007
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发表时间：
2008-02-15
影响因子：
5.1
通讯作者：
Moniuszko-Jakoniuk, Janina
中科院分区：
文献类型：
--
作者：
Brzoska, Malgorzata M.;Galazyn-Sidorczuk, Malgorzata;Moniuszko-Jakoniuk, Janina
本研究的目的是估计，在人类中度和相对较高的慢性接触镉（Cd）的大鼠模型的基础上，是否锌（Zn）的补充可以防止镉诱导的骨生物力学性能的减弱。为此目的，雄性Wistar大鼠给予镉（5或50毫克/升）或/和锌（30或60毫克/升）的饮用水为6个月和12个月。检测股骨远端和股骨干的骨密度（BMD）和生物力学性能（屈服载荷、极限载荷、屈服后载荷、屈服位移和极限位移、刚度、断裂功、屈服应力、极限应力和杨氏弹性模量）。股骨远端的生物力学性能在压缩试验中估计，而股骨干的生物力学性能在三点弯曲试验中估计。暴露于镉，在剂量和时间依赖性的方式，降低骨密度和削弱股骨远端和骨干的生物力学性能。在镉暴露过程中补充锌部分，但重要的是，防止骨生物力学性能的削弱。有利的锌的影响似乎是由于一个独立的行动，这种生物元素和它与镉的相互作用。然而，接触镉时的锌供应对股骨远端和骨干的骨密度没有统计学显著影响。本论文的结果表明，在暴露于镉补充锌可能有保护作用的骨组织的生物力学性能，并以这种方式，它可以，至少部分地，降低骨折的风险。研究结果似乎表明，增强膳食锌摄入量可能是有益的骨骼在受试者长期暴露于镉。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
The present study was aimed at estimate, based on the rat model of human moderate and relatively high chronic exposure to cadmium (Cd), whether zinc (Zn) supplementation may prevent Cd-induced weakening in the bone biomechanical properties. For this purpose, male Wistar rats were administered Cd (5 or 50 mg/l) or/and Zn (30 or 60 mg/l) in drinking water for 6 and 12 months. Bone mineral density (BMD) and biomechanical properties (yield load, ultimate load, post-yield load, displacement at yield and at ultimate, stiffness, work to fracture, yield stress, ultimate stress and Young modulus of elasticity) of the femoral distal end and femoral diaphysis were examined. Biomechanical properties of the distal femur were estimated in a compression test, whereas those of the femoral diaphysis-in a three-point bending test. Exposure to Cd, in a dose and duration dependent manner, decreased the BMD and weakened the biomechanical properties of the femur at its distal end and diaphysis. Zn supplementation during Cd exposure partly, but importantly, prevented the weakening in the bone biomechanical properties. The favorable Zn influence seemed to result from an independent action of this bioelement and its interaction with Cd. However, Zn supply at the exposure to Cd had no statistically significant influence on the BMD at the distal end and diaphysis of the femur. The results of the present paper suggest that Zn supplementation during exposure to Cd may have a protective influence on the bone tissue biomechanical properties, and in this way it can, at least partly, decrease the risk of bone fractures. The findings seem to indicate that enhanced dietary Zn intake may be beneficial for the skeleton in subjects chronically exposed to Cd. (c) 2007 Elsevier Ireland Ltd. All rights reserved.