Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research.
Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research.
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DOI：
10.3389/fpubh.2021.697381
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发表时间：
2021
影响因子：
5.2
通讯作者：
Wonkam A
中科院分区：
文献类型：
--
作者：
Fontes Marx M;Ataguba JE;de Vries J;Wonkam A
目标：多年来，关于应该退还谁和如何退还附带发现(IF)以及退还附带发现背后的伦理问题的讨论急剧增加。然而，关于将IF退还给患者的成本和收益的信息仍然很少。设计：本研究系统地回顾了基因组测序中回收IFs的经济评价。我们在Medline、Scope us、PubMed和Google Scholar中搜索已发表的关于IFS的成本效益、成本效益和成本效用的文章。结果：我们发现6篇已发表的文章符合这项研究的资格标准。两篇文章只使用了成本分析，一篇只使用了成本效益分析，两篇文章同时使用了成本分析和成本效益，还有一篇文章同时使用了成本效益分析和成本效用来描述基因组测序中返回IFs的成本。结论：虽然个人重视IF结果并愿意为其付费，但返回IF的成本取决于患者的基本健康状况。尽管患者愿意付钱，但没有明确的证据表明，退还IFS可能是划算的。需要对IFs进行更严格的经济评估研究，以确定退还IFs的成本是否对患者有利。
Objectives: Discussions regarding who and how incidental findings (IFs) should be returned and the ethics behind returning IFs have increased dramatically over the years. However, information on the cost and benefits of returning IFs to patients remains scanty. Design: This study systematically reviews the economic evaluation of returning IFs in genomic sequencing. We searched for published articles on the cost-effectiveness, cost-benefit, and cost-utility of IFs in Medline, Scopus, PubMed, and Google Scholar. Results: We found six published articles that met the eligibility criteria of this study. Two articles used cost analysis only, one used cost-benefit analysis only, two used both cost analysis and cost-effectiveness, and one used both cost-benefit analysis and cost-utility to describe the cost of returning IFs in genomic sequencing. Conclusion: While individuals value the IF results and are willing to pay for them, the cost of returning IFs depends on the primary health condition of the patient. Although patients were willing to pay, there was no clear evidence that returning IFs might be cost-effective. More rigorous economic evaluation studies of IFs are needed to determine whether or not the cost of returning IFs is beneficial to the patient.
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影响因子：
1.9
作者：
Lohn, Z.;Adam, S.;Friedman, J. M.
通讯作者：
Friedman, J. M.
通过全基因组测序确定临床可行的发现的经济证据：范围审查。
DOI：
10.1038/gim.2015.69
发表时间：
2016-02
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Douglas MP;Ladabaum U;Pletcher MJ;Marshall DA;Phillips KA
通讯作者：
Phillips KA
DOI：
10.1038/gim.2013.73
发表时间：
2013-07
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Bope, Christian Domilongo;Chimusa, Emile R.;Wonkam, Ambroise
通讯作者：
Wonkam, Ambroise
影响因子：
8.8
作者：
Christensen, Kurt D.;Vassy, Jason L.;Kong, Sek Won
通讯作者：
Kong, Sek Won