Changes in Blood Pressure in Relation to Vascular and Plasma Renin after Renin Injection in Rats
Changes in Blood Pressure in Relation to Vascular and Plasma Renin after Renin Injection in Rats
复制标题
注射肾素后大鼠血压与血管和血浆肾素的关系变化
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
H. Thurston
中科院分区：
文献类型：
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作者：
M. Loudon;R. Bing;J. Swales;H. Thurston
1.为了评估血管肾素相对于血浆肾素的相对重要性，清醒大鼠在双侧肾切除18h后单次静脉注射部分纯化的肾素。分别于注药后1、3、6、9h监测血压，测定血浆和主动脉肾素浓度。在不同组别的大鼠中，分别在注射肾素后3或6小时测量竞争性血管紧张素II拮抗剂萨拉拉辛对血压的影响。2.注射肾素后6h血压持续升高，9h恢复正常，注射萨拉拉辛后3h和6h血压的升高均被逆转。3.主动脉肾素浓度符合升压反应的规律，而血浆肾素浓度在3h时已恢复到低于正常值。4.来自肾脏的循环肾素被主动脉组织摄取。大鼠双侧肾切除后对外源性肾素的升压反应与血浆肾素的变化无关，但与主动脉肾素样活动的持续时间相似，在注射后3h和6h均可被Saralasin阻断。
1. To assess the relative importance of vascular as opposed to plasma renin, groups of conscious rats received a single intravenous injection of partially purified rat renin 18 h after bilateral nephrectomy. Blood pressure was monitored continuously and plasma and aortic renin concentrations were determined at 1, 3, 6 or 9 h after injection. In separate groups of rats the effect of the competitive angiotensin II antagonist, saralasin, on blood pressure was measured 3 or 6 h after renin injection. 2. Blood pressure remained elevated for up to 6 h after renin injection, returning to normal by 9 h. Saralasin infusion reversed the rise in blood pressure at both 3 and 6 h after injection. 3. Aortic renin concentration followed the pattern of the pressor response whereas plasma renin concentration had returned to subnormal values by 3 h. 4. Circulating renin of renal origin is taken up by aortic tissue. The pressor response to exogenous renin in rats after bilateral nephrectomy is not related to changes in plasma renin but is similar in duration to the persistence of aortic renin-like activity and can be blocked by saralasin at both 3 and 6 h after injection.