The cerebellum communicates with the basal ganglia

The cerebellum communicates with the basal ganglia
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DOI:
10.1038/nn1544
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发表时间:
2005-11-01
影响因子:
25
通讯作者:
Strick, PL
Strick, PL
中科院分区:
医学1区
文献类型:
--
作者:
Hoshi, E;Tremblay, L;Strick, PL

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大脑皮层与两个主要的皮层下结构相互连接:基底神经节和小脑。小脑回路如何以及在何处与基底神经节回路相互作用一直是一个长期存在的问题。利用猕猴狂犬病病毒的跨神经元转运,我们发现双突触通路将小脑处理的输出阶段(齿状核)与基底神经节处理的输入阶段(纹状体)联系起来。
The cerebral cortex is interconnected with two major subcortical structures: the basal ganglia and the cerebellum. How and where cerebellar circuits interact with basal ganglia circuits has been a longstanding question. Using transneuronal transport of rabies virus in macaques, we found that a disynaptic pathway links an output stage of cerebellar processing, the dentate nucleus, with an input stage of basal ganglia processing, the striatum.