Rebound insomnia and rebound anxiety: a review.
Rebound insomnia and rebound anxiety: a review.
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反弹性失眠和反弹性焦虑：回顾。
作者：
A. Kales;C. Soldatos;E. Bixler;J. Kales
反跳性失眠和反跳性焦虑是与某些苯二氮卓类药物停药相关的临床状况。在我们的睡眠实验室进行的大量苯二氮卓类和非苯二氮卓类催眠药的研究表明，在苯二氮卓类药物停药后，反弹性失眠发生，消除率快速或中等。其他研究人员进行的几项研究也表明，在类似的条件下，会出现反弹性失眠。反弹失眠和反弹焦虑的相互关系，临床意义和受体机制方面进行了讨论。有证据表明，与苯二氮卓类药物相比，产生反弹性失眠和反弹性焦虑的药物也显示出更快的耐受性发展和更大的药物依赖性潜力，因为苯二氮卓类药物的母体化合物或其代谢物具有较长的消除半衰期。
Rebound insomnia and rebound anxiety are clinical conditions related to withdrawal of certain benzodiazepine drugs. Numerous studies of benzodiazepine and nonbenzodiazepine hypnotics conducted in our sleep laboratory demonstrated that rebound insomnia developed following withdrawal from benzodiazepines with a rapid or intermediate elimination rate. Several studies conducted by other investigators also indicated the development of rebound insomnia under similar conditions. Rebound insomnia and rebound anxiety are discussed in terms of their interrelationship, clinical implications, and receptor mechanisms. Evidence suggests that drugs producing rebound insomnia and rebound anxiety also show a more rapid development of tolerance and greater potential for drug dependence than benzodiazepines where the parent compound or its metabolites have a long elimination half-life.