Peroxisome membrane proteins: multiple trafficking routes and multiple functions?
Peroxisome membrane proteins: multiple trafficking routes and multiple functions?
复制标题
DOI：
10.1042/bj20130078
复制
发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
F. Theodoulou;K. Bernhardt;N. Linka;A. Baker
中科院分区：
文献类型：
--
作者：
F. Theodoulou;K. Bernhardt;N. Linka;A. Baker
PMPs（peroxisome membrane proteins）在细胞器的生物发生中起着重要作用，并通过代谢物的运输和氧化还原梭的运作协调过氧化物酶体代谢与其他亚细胞区室中的途径。虽然进口到过氧化物酶体基质的可溶性蛋白质已经得到了很好的研究，少得多的是已知的PMP的贩运。Pex 3和Pex 19（以及哺乳动物中的Pex 16）在十多年前被鉴定为PMP输入的关键组分;然而，已经证明难以产生它们在PMP输入和过氧化物酶体生物发生中的功能的统一模型。很明显，这些过氧化物都有多种功能，在本综述中，我们专注于经典的和最近确定的角色Pex 19和Pex 3的结构，生物化学和活细胞成像研究。我们认为不同的模型提出的过氧化物酶体的生物合成和PMP进口的作用，并提出的差异可能比真实的，并反映了高度动态性质的过氧化物酶体。
PMPs (peroxisome membrane proteins) play essential roles in organelle biogenesis and in co-ordinating peroxisomal metabolism with pathways in other subcellular compartments through transport of metabolites and the operation of redox shuttles. Although the import of soluble proteins into the peroxisome matrix has been well studied, much less is known about the trafficking of PMPs. Pex3 and Pex19 (and Pex16 in mammals) were identified over a decade ago as critical components of PMP import; however, it has proved surprisingly difficult to produce a unified model for their function in PMP import and peroxisome biogenesis. It has become apparent that each of these peroxins has multiple functions and in the present review we focus on both the classical and the more recently identified roles of Pex19 and Pex3 as informed by structural, biochemical and live cell imaging studies. We consider the different models proposed for peroxisome biogenesis and the role of PMP import within them, and propose that the differences may be more perceived than real and may reflect the highly dynamic nature of peroxisomes.