Impact of comorbidity and ageing on health-related quality of life in HIV-positive and HIV-negative individuals
Impact of comorbidity and ageing on health-related quality of life in HIV-positive and HIV-negative individuals
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DOI：
10.1097/qad.0000000000001511
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发表时间：
2017-06-01
期刊：
影响因子：
3.8
通讯作者：
Nieuwkerk, Pythia T.
中科院分区：
文献类型：
--
作者：
Langebeek, Nienke;Kooij, Katherine W.;Nieuwkerk, Pythia T.
背景：艾滋病毒感染者可能面临与年龄相关的非传染性合并症过早发病的风险。 HIV 呈阳性、患有合并症和年龄较大可能会对健康相关的生活质量 (HRQL) 产生不利影响。我们调查了 HIV 感染、合并症和年龄对 HRQL 和抑郁症的可能影响。方法：对 AGE(h)IV 队列研究中的 HIV 感染者和未感染对照进行筛查，以确定是否存在合并症。他们完成了包含 36 项的简短健康调查来评估 HRQL，并完成了包含 9 项的患者健康调查问卷来评估抑郁症。使用线性和逻辑回归来调查合并症、衰老和 HIV 感染在多大程度上与 HRQL 和抑郁症独立相关。 结果：HIV 感染者 (n = 541) 报告的身体和心理 HRQL 明显较差，并且抑郁症患病率高于 HIV 未感染者 (n = 526)。较高数量的合并症和 HIV 阳性状态均与较差的身体 HRQL 独立相关，而 HIV 阳性状态和较年轻的年龄则与较差的心理 HRQL 和更多抑郁独立相关。 HIV 阳性和 HIV 阴性个体之间的身体 HRQL 差异并没有随着合并症数量的增加或年龄的增加而变得更大。 结论：在一组基本上受到良好抑制的 HIV 阳性参与者和 HIV 阴性对照中，HIV 阳性状态与较差的身体和心理 HRQL 以及抑郁的可能性增加显着且独立相关。我们发现，更多的合并症与较差的身体 HRQL 独立相关，这强化了随着 HIV 感染人群持续老龄化，优化合并症的预防和管理的重要性。版权所有 (C) 2017 Wolters Kluwer Health, Inc. 保留所有权利。
Background: HIV-infected individuals may be at risk for the premature onset of age-associated noncommunicable comorbidities. Being HIV-positive, having comorbidities and being of higher age may adversely impact health-related quality of life (HRQL). We investigated the possible contribution of HIV infection, comorbidities and age on HRQL and depression.Methods: HIV-infected individuals and uninfected controls from the AGE(h)IV Cohort Study were screened for the presence of comorbidities. They completed the Short Form 36-item Health Survey to assess HRQL and the nine-item Patient Health Questionnaire to assess depression. Linear and logistic regression were used to investigate to which extent comorbidities, aging and HIV infection were independently associated with HRQL and depression.Results: HIV-infected individuals (n = 541) reported significantly worse physical and mentalHRQLand had a higher prevalence of depression than HIV-uninfected individuals (n = 526). A higher number of comorbidities and HIV-positive status were each independently associated with worse physical HRQL, whereas HIV-positive status and younger age were independently associated with worse mental HRQL and more depression. The difference in physical HRQL between HIV-positive and HIV-negative individuals did not become greater with a higher number of comorbidities or with higher age.Conclusion: In a cohort of largely well suppressed HIV-positive participants and HIV-negative controls, HIV-positive status was significantly and independently associated with worse physical and mental HRQL and with an increased likelihood of depression. Our finding that a higher number of comorbidities was independently associated with worse physical HRQL reinforces the importance to optimize prevention and management of comorbidities as the HIV-infected population continues to age. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.