THE EFFECTS OF CHRONIC AMPHETAMINE ADMINISTRATION ON THE ACQUISITION AND EXTINCTION OF AN ACTIVE AND PASSIVE-AVOIDANCE RESPONSE IN MICE
THE EFFECTS OF CHRONIC AMPHETAMINE ADMINISTRATION ON THE ACQUISITION AND EXTINCTION OF AN ACTIVE AND PASSIVE-AVOIDANCE RESPONSE IN MICE
复制标题
DOI：
10.1016/0091-3057(83)90333-7
复制
发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
KOKKINIDIS, L
中科院分区：
文献类型：
--
作者：
KOKKINIDIS, L
长期安非他明治疗对主动或被动回避反应的获得或保持没有影响。在这两项任务中，与对照组相比，长期停用安非他明的小鼠表现出对灭绝的抵抗力。这些发现与长期服用安非他明对注意力过程的影响有关。讨论了控制慢性暴露于安非他明引起的注意力缺陷的可能的神经化学机制。
Long-term amphetamine treatment had no effect on the acquisition or retention of an active or passive avoidance response. In both tasks, mice withdrawn from chronic amphetamine administration showed a resistance to extinction relative to control animals. These findings were related to the effects of long-term amphetamine administration on attentional processes. Possible neurochemical mechanisms governing the attentional deficits induced by chronic exposure to amphetamine were discussed.