Frequency of Human Papillomavirus Infection, Coinfection, and Association with Different Risk Factors in Colombia
Frequency of Human Papillomavirus Infection, Coinfection, and Association with Different Risk Factors in Colombia
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DOI：
10.1016/j.annepidem.2010.11.003
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发表时间：
2011-03-01
影响因子：
5.6
通讯作者：
Patarroyo, Manuel A.
中科院分区：
文献类型：
--
作者：
Camargo, Milena;Soto-De Leon, Sara C.;Patarroyo, Manuel A.
目得：这项研究的目的是提供新的见解感染模式的六个高危人乳头瘤病毒（HR-HPV-16、-18、-31、-33、-45和-58）和两种低风险HPV类型（LR-HPV-6和-11），它们与危险因素和合并感染的关联。采用聚合酶链反应检测2110例妇女宫颈标本中HPV DNA的存在。进行统计分析，以确定病毒类型的频率在单一和多重感染和感染之间的关联和不同的危险factors.Results：HPV-16是研究人群中最流行的类型，其次是HPV-31。最后一种病毒类型在所评估的不同城市之间显示出可变的分布。结果表明，不同类型的特定区域之间的分布和高度关联之间没有怀孕，城市Girardot和莱蒂西亚，土著民族，和coinfection.CONCLUSIONS：结果显示了可变的HPV类型的分布，根据地理区域分析。此外，数据表明，一些社会人口因素，如种族，怀孕次数，性伴侣的一生数量和地理区域显着相关，我们的结果显示，HPV单次和多次感染之间的风险因素差异不大。此外，这些结果提供了相关信息，可以在进一步的研究中评估疫苗接种计划对这些人群的影响以及选择性压力对HPV类型分布的影响。Ann Epidemiol 201121：204-213. (C)2011 Elsevier Inc. All rights reserved.
PURPOSE: The aims of this study were to provide new insights into infection patterns of six high-risk human papillomaviruses (HR-HPV-16, -18, -31, -33, -45, and -58) and two low-risk HPV types (LR-HPV-6 and -11), their association with risk factors and coinfection.METHODS: Cervical samples of 2110 women were tested for the presence of HPV DNA by polymerase chain reaction. Statistical analyses were performed to determine viral-type frequencies in single and multiple infections and association between infection and different risk factors.RESULTS: HPV-16 was the most prevalent type among the studied population, followed by HPV-31. This last viral type showed a variable distribution between the different cities evaluated. The results showed distinct type-specific distributions among regions and a high association between absence of pregnancies, cities as Girardot and Leticia, the indigenous ethnicity, and coinfection.CONCLUSIONS: The results showed a variable distribution of HPV types according to the geographical region analyzed. In addition, data suggest that some sociodemographic-factors such as ethnicity, number of pregnancies, lifetime number of sexual partners, and geographic region were significantly associated, and our results showed little differences between single and multiple infections by HPV with regard to risk factors. Furthermore, these results provide relevant information that will allow assessing in further studies the impact that vaccination programs on these populations and the selective pressure would have on the distribution of HPV types. Ann Epidemiol 201121:204-213. (C) 2011 Elsevier Inc. All rights reserved.