The Wnt signaling pathway and rheumatoid arthritis
The Wnt signaling pathway and rheumatoid arthritis
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DOI：
10.1016/j.autrev.2009.08.003
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发表时间：
2010-02-01
影响因子：
13.6
通讯作者：
Amato, Angelica Amorim
中科院分区：
文献类型：
--
作者：
Rabelo, Francieli de Sousa;Henrique da Mota, Licia Maria;Amato, Angelica Amorim
Wnt信号通路在细胞更新中起着关键作用，有两种这样的通路。在类风湿性关节炎（RA）患者中，滑膜表达的基因，如Wnt和Fz在更高的水平比那些观察到的非RA患者。Wnt蛋白是与细胞表面上的Fz家族的受体结合的糖蛋白。Wnt/Fz复合体控制胚胎发生期间的组织形成，以及整个肢体发育和关节形成的过程。最近的研究表明，这一信号通路在RA的病理生理学中发挥作用。更多地了解Writ信号通路在RA中的作用可以提高对RA临床表现和预后差异的理解。进一步的研究还应关注Wnt家族成员作为治疗RA的分子靶点。(C)2009 Elsevier B. V.版权所有
The Wnt signaling pathways play a key role in cell renewal, and there are two such pathways. In patients with rheumatoid arthritis (RA), the synovial membrane expresses genes such as Wnt and Fz at higher levels than those observed in patients without RA. The Wnt proteins are glycoproteins that bind to receptors of the Fz family on the cell surface. The Wnt/Fz complex controls tissue formation during embryogenesis, as well as throughout the process of limb development and joint formation. Recent studies have suggested that this signaling pathway plays a role in the pathophysiology of RA. Greater knowledge of the role of the Writ signaling pathway in RA could improve understanding of the differences in RA clinical presentation and prognosis. Further studies should also focus on Wnt family members as molecular targets in the treatment of RA. (C) 2009 Elsevier B.V. All rights reserved