Biological Effects of Deuterium
Biological Effects of Deuterium
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氘的生物效应
DOI：
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
C. V. von Essen
中科院分区：
文献类型：
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作者：
C. V. von Essen
引入和去除氨基酸封闭基。第二节讨论耦合方法，几篇论文讨论了外消旋化问题。特别有趣的是，有一份报告使用了一种气相色谱技术来比较各种常用的偶联技术的消旋程度。第三节讨论了“非天然”氨基酸的存在以及含有这种氨基酸的抗菌肽的合成中所涉及的特殊问题。这一部分的第一章是对该领域有价值的全面回顾，引用了270篇参考文献。简短的第四节简要讨论了与合成问题无关的两个方面：多肽在溶液中的构象，以及多肽在半胱氨酸和丝氨酸残基上的非酶切割。最后一节是最短的，但仍然是一个宝贵的贡献。这是命名委员会的报告，并就氨基酸衍生物和氨基酸序列的统一公式编写系统提出了建议。希望未来的作者将像本书的贡献者一样严格关注这些规则。这种类型的书，尽管它的结构很好，但就其本质而言，一定是某种程度上的信息大杂烩。这并不会减损其价值。大量有趣和有用的化学信息被呈现在有限的空间中。这本书肯定是推荐给任何对合成肽化学感兴趣的人的有价值的参考。这是国际纯生物学和应用生物学系列丛书的第19卷。所研究的大多数反应与D20(“重水”)的使用有关。该化合物的作用从物理方面开始，通过酶反应的进展，对微生物、低等动植物的影响，最后到对完整的哺乳动物的影响，给出了一个连续的介绍。关于D20与生物物体辐射敏感性的关系的简短一章强调了这一领域结果的矛盾性质。这一卷代表了文献的回顾，并包含作者和主题索引。这是一个非常短的生物学历史，并遭受了在这样有限的范围内不可避免的一些错误。在从古代到17世纪的广泛的历史范围内，作者的处理是印象派的，肤浅的，并严重受惠于像辛格和诺登斯科尔德这样的较古老的历史。The…
introducing and removing amino acid blocking groups. Section II deals with coupling methods, and several papers take up the problem of racem-ization. Especially interesting is a report of the use of a gas chromatographic technique to compare the degree of racemization by various commonly used coupling techniques. The third section discusses the occurrence of "unnatural" amino acids and special problems involved in the synthesis of antibiotic peptides that contain such amino acids. The first chapter in this section is a valuable comprehensive review of this field with 270 references. A short fourth section briefly discusses two aspects of peptide chemistry unrelated to synthetic problems: the conformation of peptides in solution, and nonenzymic cleavage of peptides at cysteine and serine residues. The final section is the shortest, but nevertheless is a valuable contribution. It is the report of the committee on nomenclature with recommendations for a uniform system of writing formulas for amino acid derivatives and amino acid sequences. It is to be hoped that future authors will pay as strict attention to these rules as have the contributors to this particular volume. A book of this type, in spite of its excellent organization, must, by its very nature, be somewhat of a potpourri of information. This does not detract form its value. A great deal of interesting and useful chemical information is presented in a limited space. The book is certainly to be recommended as a valuable reference for anyone actively interested in synthetic peptide chemistry. This is volume 19 of the International Series of Monographs on Pure and Applied Biology. The majority of reactions studied relate to the use of D20 ("heavy water"). A sequential presentation of the actions of this compound is given, beginning with physical aspects, progressing through enzymatic reactions, effects on microorganisms , lower animals and plants, and ending with effects on intact mammals. A brief chapter on the relationship of D20 to radiation sensitivity of biological objects emphasizes the contradictory nature of the results in this area. This volume represents a review of the literature and contains an author and subject index. This is a very short history of biology and suffers from some of the faults inevitable within such confined limits. Over the broad ranges of history extending from antiquity to the seventeenth century the author's treatment is impressionistic, superficial, and heavily indebted to such older histories as those of Singer and Nordenskiold. The …