Autophagy, myocardial protection, and the metabolic syndrome.
Autophagy, myocardial protection, and the metabolic syndrome.
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DOI：
10.1097/fjc.0b013e318256ce10
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发表时间：
2012-08
影响因子：
3
通讯作者：
Gottlieb RA
中科院分区：
文献类型：
--
作者：
Giricz Z;Mentzer RM Jr;Gottlieb RA
自噬是一种有助于维持细胞能量稳态和清除受损细胞器的内务过程。在心脏中，自噬是一种适应过程，在应激反应中被激活，包括急性和慢性缺血。鉴于有证据表明自噬在能量丰富的情况下受到抑制，本综述的目的是研究代谢综合征背景下的自噬和心脏保护。临床方法涉及诱导心脏自噬的药理学，以提高心脏的耐受性缺血也进行了讨论。
Autophagy is a housekeeping process which helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given the evidence that autophagy is suppressed in energy-rich conditions, the objective of this review is to examine autophagy and cardioprotection in the setting of the metabolic syndrome. Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart’s tolerance to ischemia are also discussed.