A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis
A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis
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DOI：
10.1128/iai.73.6.3806-3809.2005
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发表时间：
2005-06-01
影响因子：
3.1
通讯作者：
Bayer, AS
中科院分区：
文献类型：
--
作者：
McNamara, PJ;Bayer, AS
rot中的突变恢复了金黄色葡萄球菌agr阴性菌株的体外毒素生产。我们表明，一个rot突变返回野生型的毒性agr突变，在实验性心内膜炎感染的靶器官细菌计数测量。我们的数据的影响进行了讨论agr拮抗剂的策略。
Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.