Changes in plasma cholecystokinin concentrations after oral glucose tolerance test in anorexia nervosa before and after therapy.
Changes in plasma cholecystokinin concentrations after oral glucose tolerance test in anorexia nervosa before and after therapy.
复制标题
神经性厌食症治疗前后口服葡萄糖耐量试验后血浆胆囊收缩素浓度的变化。
DOI：
10.1016/0026-0495(93)90216-b
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
T. Nakagawa
中科院分区：
文献类型：
--
作者：
H. Tamai;J. Takemura;N. Kobayashi;S. Matsubayashi;S. Matsukura;T. Nakagawa
有相当多的证据表明，胃肠激素胆囊收缩素（CCK）诱导饱腹感，减少动物和人类的食物摄入量。最近有报道称，神经性贪食症（BN）患者的CCK分泌受损，其血浆CCK对标准化混合液体餐的反应显着低于对照组。本研究旨在探讨另一种较为常见的进食障碍--神经性厌食症（anorexia nervosa，AN）患者治疗前后CCK水平是否异常，并探讨其与异常进食行为的关系。血浆CCK，血糖，和免疫反应性胰岛素（IRI）的反应，以50克口服葡萄糖负荷测定13名女性与AN和9名正常的性别和年龄匹配的对照。AN患者在治疗期间全部住院;在体重部分恢复后，重复测试。初始体重为理想体重（IBW）的70.8% ± 1.8%（平均值± SEM），部分恢复后为84.3% ± 1.4%。正常对照组体重为IBW的96.3% ± 2.1%。在营养和认知行为治疗前，AN患者的初始基础CCK浓度显著高于对照组（P<0.01）。体重部分恢复后，AN患者的基础CCK浓度接近对照组。当AN患者在治疗前给予葡萄糖负荷时，与对照组相比，CCK反应的变化减少。然而，治疗后AN患者对葡萄糖负荷的CCK反应与对照组相似。口服葡萄糖负荷后的血糖水平与对照组基本相同;然而，AN患者治疗前后葡萄糖负荷后IRI水平的变化显著低于对照组。这些数据表明，AN患者的基础CCK水平异常升高，并且对口服葡萄糖负荷的反应减弱在治疗和体重部分恢复后基本上正常化。AN中基础CCK水平升高的意义仍有待阐明。
There is considerable evidence that the gastrointestinal hormone cholecystokinin (CCK) induces satiety and reduces food intake in both animals and humans. Impaired CCK secretion was recently reported in patients with bulimia nervosa (BN) in whom plasma CCK responses to a standardized mixed-liquid meal were significantly lower than in controls. The present study was undertaken to determine whether CCK levels were abnormal in another relatively common eating disorder, anorexia nervosa (AN), before and after therapy and to investigate the relationship to the abnormal eating behavior. Plasma CCK, serum glucose, and immunoreactive insulin (IRI) responses to a 50-g oral glucose load were measured in 13 women with AN and in nine normal sex- and age-matched controls. The AN patients were all hospitalized during treatment; following partial restoration of body weight, the tests were repeated. Initial body weights were 70.8% ± 1.8% (mean ± SEM) of ideal body weight (IBW), and following partial restoration were 84.3% ± 1.4%. Body weights in normal controls were 96.3% ± 2.1% of IBW. Initial basal CCK concentrations in the AN patients before nutritional and cognitive behavioral therapy were significantly greater than those in controls (P< .01). After partial restoration of body weight, basal CCK concentration in AN patients approached that of control subjects. When AN patients were given a glucose load before therapy, the change in CCK response was diminished when compared with that of controls. However, CCK responses to the glucose load in AN patients following therapy were similar to those of controls. Blood glucose levels following the oral glucose load were essentially the same as those observed in the controls; however, changes in levels of IRI following the glucose load in AN patients before and after treatment were significantly less than those in the controls. These data indicate that basal CCK levels are abnormally elevated in AN patients, and that diminished responses to an oral glucose load are essentially normalized after therapy and partial restoration of body weight. The significance of the elevated basal CCK levels in AN remains to be elucidated.
饮食和情感障碍中与膳食相关的胆囊收缩素分泌。
影响因子：
--
作者：
GeraciotiJr,TD;Kling,MA;Joseph-Vanderpool,JR;Kanayama,S;Rosenthal,NE;Gold,PW;Liddle,RA
通讯作者：
Liddle,RA