Small noncoding RNAs controlling pathogenesis.
Small noncoding RNAs controlling pathogenesis.
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DOI：
10.1016/j.mib.2007.03.004
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发表时间：
2007-04
影响因子：
5.4
通讯作者：
Alejandro Toledo-Arana;F. Repoila;P. Cossart
中科院分区：
文献类型：
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作者：
Alejandro Toledo-Arana;F. Repoila;P. Cossart
传染病是世界范围内死亡的主要原因。实现根除它们的一个主要挑战是更好地了解细菌的致病过程。最近发现的小非编码RNA(SRNAs)作为基因表达的调节器响应环境线索，为细菌调控带来了新的见解。SRNA协调逆境适应和毒力基因表达的复杂网络。一般情况下，sRNA通过与效应器和/或调控基因的mRNA配对或通过与蛋白质结合来确保这种调节。关于导致重要感染的细菌模型的最新观点说明了sRNAs在致病控制中的关键作用
Infectious diseases are a leading cause of mortality worldwide. A major challenge in achieving their eradication is a better understanding of bacterial pathogenesis processes. The recent discovery of small noncoding RNAs (sRNAs) as modulators of gene expression in response to environmental cues has brought a new insight into bacterial regulation. sRNAs coordinate complex networks of stress adaptation and virulence gene expression. sRNAs generally ensure such a regulation by pairing to mRNAs of effector and/or regulatory genes, or by binding to proteins. An updated view on bacterial models responsible for important infections illustrates the key role of sRNAs in the control of pathogenesis