Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia.
Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia.
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DOI：
10.2147/jpr.s40967
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发表时间：
2013
影响因子：
2.7
通讯作者：
Morita K
中科院分区：
文献类型：
--
作者：
Mizobuchi S;Kanzaki H;Omiya H;Matsuoka Y;Obata N;Kaku R;Nakajima H;Ouchida M;Morita K
众所周知，周围神经损伤引起背根神经节中某些生长因子的表达改变。据报道，在脊髓背角周围神经损伤后，ErbB受体（一种在体细胞中众所周知的生长因子）的表达发生改变；然而，神经损伤后背根神经节中这些受体的表达是否发生改变尚不清楚。因此，本研究以L5选择性脊神经结扎模型大鼠为外周神经损伤模型，检测双侧腰(L)4/L5背根神经节ErbB受体的基因表达谱。成熟大鼠背根神经节中可见ErbB2和ErbB3的表达，而ErbB1和ErbB4仅微弱表达。我们还证明，与未损伤的神经相比，周围神经损伤诱导同侧背根神经节ErbB2和ErbB3显著增加。ErbB受体的表达变化似乎在神经损伤和随后的神经再生中起重要作用。
It is generally known that peripheral nerve injury causes changes in expression of some growth factors in the dorsal root ganglion. Altered expression of ErbB receptors, a well-known growth factor in somatic cells, reportedly follows peripheral nerve injury in the spinal dorsal horn; however, it remains unknown whether the expression of these receptors is altered in the dorsal root ganglion after nerve injury. Therefore, this study examined the gene expression profiles of ErbB receptors in bilateral lumbar (L)4/L5 dorsal root ganglia, using L5-selective spinal nerve ligation in model rats as a peripheral nerve injury model. The expression of ErbB2 and ErbB3 was observed in the dorsal root ganglia of the mature rat, despite ErbB1 and ErbB4 showing only subtle expression. We also demonstrated that peripheral nerve injury induced significant increases in ErbB2 and ErbB3 in the ipsilateral dorsal root ganglion as compared with uninjured nerve. Expression changes in ErbB receptors appear to play important roles in nerve injury and subsequent nerve regeneration.