Serum Adipocyte Fatty Acid Binding Protein Levels Are Positively Associated With Subclinical Atherosclerosis in Chinese Pre- and Postmenopausal Women With Normal Glucose Tolerance
Serum Adipocyte Fatty Acid Binding Protein Levels Are Positively Associated With Subclinical Atherosclerosis in Chinese Pre- and Postmenopausal Women With Normal Glucose Tolerance
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中国绝经前和绝经后糖耐量正常女性血清脂肪细胞脂肪酸结合蛋白水平与亚临床动脉粥样硬化呈正相关
DOI：
10.1210/jc.2014-1832
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发表时间：
2014-11-01
影响因子：
5.8
通讯作者：
Jia, Weiping
中科院分区：
文献类型：
--
作者：
Hao, Yaping;Ma, Xiaojing;Jia, Weiping
背景：最近的研究强调了脂肪细胞脂肪酸结合蛋白（A-FABP）和心血管疾病之间的重要相互作用。然而，A-FABP与糖耐量正常人群亚临床动脉粥样硬化的关系尚不清楚。目的：本研究旨在评估中国糖耐量正常人群A-FABP与颈动脉内膜中层厚度（C-IMT）之间的关系。设计和设置：对2253名无心血管疾病的正常糖耐量受试者进行了横断面分析主要结果和指标：采用B超测量C-IMT，并用于评估亚临床动脉粥样硬化。结果：血清A-FABP水平中位数为4.0ng/mL（四分位数范围：2.6- 6.0ng/mL），女性显著高于男性（P <0.001）。校正年龄和体重指数（BMI）后，偏相关分析显示，男性、绝经前和绝经后女性A-FABP水平与C-IMT相关（分别为P <0.024，0.006和0.016）。此外，C-IMT随着四分位数A-FABP值的增加而沿着增加（趋势P均<0.001）。回归分析表明，A-FABP仅与女性C-IMT相关（绝经前和绝经后分别为P = 0.044和0.001）。此外，A-FABP被确定为一个危险因素，C-IMT在绝经前和绝经后妇女与正常的BMI（P <0.001和P = 0.012，分别）。结论：血清A-FABP水平与亚临床动脉粥样硬化在绝经前和绝经后的中国妇女与正常的葡萄糖耐量调整后的传统危险因素。
Context: Recent studies highlight a critical interaction between adipocyte fatty acid binding protein (A-FABP) and cardiovascular disorders. However, associations of A-FABP with subclinical atherosclerosis in a population with normal glucose tolerance remain unknown.Objective: The study aimed to evaluate the relationship between A-FABP and carotid intima-media thickness (C-IMT) in a Chinese population with normal glucose tolerance.Design and Setting: A cross-sectional analysis was conducted of 2253 cardiovascular disease-free normal glucose tolerance subjects (835 men, 1418 women; 20-78 years old) from the Shanghai Obesity Study.Main Outcome and Measures: C-IMT was measured by B-mode ultrasound and used to assess subclinical atherosclerosis. Serum A-FABP levels were quantified by a sandwich ELISA.Results: The median serum level for A-FABP was 4.0 ng/mL (interquartile range: 2.6-6.0 ng/mL), and significantly higher inwomenthanmen(P < .001). After adjusting for age and body mass index (BMI), a partial correlation analysis showed that A-FABP levels correlated with C-IMT in men, premenopausal, and postmenopausalwomen(P < .024,.006, and.016, respectively). Furthermore, C-IMT increased along with quartile A-FABP values (all P for trend < .001). Regression analyses demonstrated that A-FABP was associated with C-IMT only in women (P = .044 and .001 for pre and postmenopausal, respectively). Moreover, A-FABP was identified as a risk factor for C-IMT in pre- and postmenopausal women with a normal BMI (P < .001 and P = .012, respectively).Conclusions: Serum A-FABP levels independently and positively correlate with subclinical atherosclerosis in pre-and postmenopausal Chinese women with normal glucose tolerance after adjustments for the traditional risk factors.