Age-associated changes in rhesus CNS composition identified by MRI
Age-associated changes in rhesus CNS composition identified by MRI
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DOI：
10.1016/s0006-8993(99)01343-8
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发表时间：
1999-05-22
期刊：
影响因子：
2.9
通讯作者：
Avison, MJ
中科院分区：
文献类型：
--
作者：
Andersen, AH;Zhang, ZM;Avison, MJ
对10只年轻猕猴(5-8岁)、10只中年恒河猴(12-17岁)和11只老年(21-27岁)雌性恒河猴的磁共振图像进行了多光谱自动分割，揭示了大脑体积和组成随年龄的变化。总的脑实质体积(表示为颅内体积-%ICV)以0.3+/-0.04%ICV/年的线性速率减少。到15岁时，这种丢失几乎完全是由于灰质丢失，伴随着脑脊液(CSF)的代偿性增加，可能还有一些脑白质。脑组织成分，以灰质/白质体积比表示，证实灰质丢失超过白质丢失，但灰白比的下降速度在大约15年后开始放缓。将恒河猴大脑的这些与年龄相关的变化与人类的大脑变化进行比较表明，恒河猴的大脑老化是人类大脑老化的一个很好的模型，但发生的速度类似于人类的3倍。(C)1999 Elsevier Science B.V.保留所有权利。
Multispectral automated segmentation of MR images of the brains of 10 young (5-8 years), 10 middle-aged (12-17 years), and 11 old (21-27 years) female rhesus monkeys revealed age-associated changes in brain volume and composition. Total brain parenchymal volume (expressed as fraction of intracranial volume-%ICV) decreased at a linear rate of 0.3 +/- 0.04% ICV/year. Up to age similar to 15 years, this loss was almost entirely due to gray matter loss, with a compensatory increase in cerebrospinal fluid (CSF), and possibly some white matter. Brain tissue composition, expressed as the gray matter/white matter volume ratio confirmed that gray matter loss exceeded white matter loss, but the rate of decline in the gray/white ratio began to slow after similar to 15 years. Comparison of these age-associated changes in rhesus brain with those in humans suggest that the brain aging in rhesus is a good model of human brain aging, but occurs similar to 3-fold faster. (C) 1999 Elsevier Science B.V. All rights reserved.