Effects of Parkinson's disease and levodopa on functional limits of stability
Effects of Parkinson's disease and levodopa on functional limits of stability
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DOI：
10.1016/j.clinbiomech.2007.11.007
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发表时间：
2008-05-01
影响因子：
1.8
通讯作者：
Chiari, Lorenzo
中科院分区：
文献类型：
--
作者：
Mancini, Martina;Rocchi, Laura;Chiari, Lorenzo
背景自愿的、最大倾斜的姿势反映了自我感知的稳定极限。帕金森氏病与站立时的小的、运动迟缓的姿势性体重转移有关，但目前尚不清楚这是否是由于稳定性限制降低和/或选择了异常的倾斜策略。本研究的目的是调查帕金森病和左旋多巴药物对稳定性自愿极限的影响以及达到这些极限的策略。14名患有帕金森病的受试者（左旋多巴关闭和打开）和10名年龄匹配的对照组参与了这项研究。稳定性的功能极限被量化为在自愿向前和向后倾斜期间的最大压力偏移中心。姿势策略，以实现稳定性的功能限制进行了评估（一）身体节段对齐，（二）压力中心和质心之间的差异，在准备倾斜，（三）的时间和速度的准备阶段。与对照组相比，帕金森病受试者的稳定性功能极限明显较小。帕金森病患者在倾斜时保持其弯腰姿势，与对照组相比，开始倾斜时压力中心和质量中心之间的差异较小，并且倾斜速度较慢。左旋多巴扩大了帕金森病患者的稳定性极限，因为最大前倾增加，但不是向后倾斜，但没有显着改善姿势对齐，倾斜运动的准备，或倾斜速度。帕金森氏病降低了稳定性的功能极限以及站立时随意向前和向后倾斜时姿势准备的幅度和速度。左旋多巴改善了稳定性的极限，但不能改善用于实现倾斜的姿势策略。(c)2007爱思唯尔有限公司保留所有权利。
Background The voluntary, maximum inclined posture reflects the self-perceived limits of stability. Parkinson's disease is associated with small, bradykinetic postural weight shifts while standing but it is unclear whether this is due to reduced limits of stability and/or to the selection of abnormal strategies for leaning. The aim of this study was to investigate the effects of Parkinson's disease and levodopa medication on voluntary limits of stability and strategies used to reach these limits.Methods. Fourteen subjects with Parkinson's disease (OFF and ON levodopa) and 10 age-matched controls participated in the study. Functional limits of stability were quantified as the maximum center of pressure excursion during voluntary forward and backward leaning. Postural strategies to achieve functional limits of stability were assessed by (i) body segments alignment, (ii) the difference between center of pressure and center of mass in preparation for a lean, (iii) the timing and the velocity of the preparation phase.Findings. Functional limits of stability were significantly smaller in subjects with Parkinson's disease compared to control subjects. Subjects with Parkinson's disease maintained their stooped posture while leaning, initiated leaning with a smaller difference between center of pressure and center of mass and had a slower leaning velocity compared to control subjects. Levodopa enlarged the limits of stability in subjects with Parkinson's disease because of an increase in maximum forward, but not backward leans, but did not significantly improve postural alignment, preparation for a leaning movement, or velocity of leaning.Interpretation. Parkinson's disease reduces functional limits of stability as well as the magnitude and velocity of postural preparation during voluntary, forward and backward leaning while standing. Levodopa improves the limits of stability but not the postural strategies used to achieve the leaning. (c) 2007 Elsevier Ltd. All rights reserved.