Chronic ethanol administration induced an increase in phosphatidylserine in guinea pig synaptic plasma membranes.
Chronic ethanol administration induced an increase in phosphatidylserine in guinea pig synaptic plasma membranes.
复制标题
长期服用乙醇会诱导豚鼠突触质膜中磷脂酰丝氨酸的增加。
DOI：
10.1016/0006-291x(83)90460-6
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发表时间：
1983
影响因子：
3.1
通讯作者：
Sun,AY
中科院分区：
文献类型：
--
作者：
Sun,GY;Sun,AY
通过胃内插管对豚鼠进行慢性乙醇给药引起突触质膜中磷脂酰丝氨酸的特异性增加（50%）。乙醇处理组的突触体（Na，K）-ATP酶活性也增加了53%。在相同的膜馏分中的单个磷脂的酰基组合物的分析显示，只有很小的变化，这取决于磷脂的类型。由于已知（Na，K）-ATP酶被磷脂酰丝氨酸特异性激活，因此慢性乙醇处理期间酶活性的适应性增加可能与这种带负电荷的磷脂的增加有关。
Chronic ethanol administration to guinea pigs via intragastric intubation elicited a specific increase (50%) in phosphatidylserine in the synaptic plasma membrane. The ethanol-treated group also showed a 53% increase in synaptosomal (Na,K)-ATPase activity. Analysis of the acyl group composition of individual phospholipids in the same membrane fraction revealed only small changes which varied depending on the type of phospholipids. Since the (Na,K)-ATPase is known to be specifically activated by phosphatidylserine, the adaptive increase in enzyme activity during chronic ethanol treatment may be related to the increase in this type of negatively charged phospholipid.