THE TIME COURSE OF STEROID ACTION ON BLOOD-TO-BRAIN AND BLOOD-TO-TUMOR TRANSPORT OF RB-82 - A POSITRON EMISSION TOMOGRAPHIC STUDY
THE TIME COURSE OF STEROID ACTION ON BLOOD-TO-BRAIN AND BLOOD-TO-TUMOR TRANSPORT OF RB-82 - A POSITRON EMISSION TOMOGRAPHIC STUDY
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DOI：
10.1002/ana.410250306
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发表时间：
1989-03-01
影响因子：
11.2
通讯作者：
ROTTENBERG, DA
中科院分区：
文献类型：
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作者：
JARDEN, JO;DHAWAN, V;ROTTENBERG, DA
应用82Rb和正电子发射断层扫描，对8例原发或转移性脑肿瘤患者静脉注射100 mg地塞米松前和注射后约6小时的Rb(K1)和Vb(表观组织血容量)的血到脑和血到肿瘤的转运速率常数进行了估算。对另外8名患者进行了研究，以评估重测变异性和重新定位误差。给予地塞米松6小时后，肿瘤K1(但不是VB)与对侧对照脑区相比显著减少(p<；0.03)。这些数据与我们之前发表的地塞米松后24小时的数据一致，并表明皮质类固醇对脑/肿瘤毛细血管的类似影响可能在5至6小时和24小时观察到。地塞米松引起的脑/肿瘤毛细血管通透性改变的时间进程支持这样的观点，即这些改变可能至少与皮质类固醇的部分抗水肿作用有关。
Blood-to-brain and blood-to-tumor transport rate constants for Rb (K1) and apparent tissue blood volume (Vb) were estimated in 8 patients with primary or metastatic brain tumors before and approximately 6 hours after a 100-mg intravenous bolus injection of dexamethasone using 82Rb and positron emission tomography. Eight additional patients were studied to evaluate test-retest variability and repositioning errors. Six hours following dexamethasone administration tumor K1 (but not Vb) was significantly reduced compared with contralateral control brain regions (p < 0.03). These data are consistent with our previously published 24-hour-postdexamethasone data and suggest that comparable effects of corticosteroids on brain/tumor capillaries may be observed at 5 to 6 and 24 hours. The time course of dexamethasone-induced alterations in brain/tumor capillary permeability supports the view that these alterations may be responsible for at least some of the antiedema effects of corticosteroids.