Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs.
Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs.
复制标题
偏头痛患者总氧化状态水平升高，芳基酯酶活性降低。
DOI：
10.1016/j.clinbiochem.2011.04.015
复制
发表时间：
2011
影响因子：
2.8
通讯作者：
E. Eren
中科院分区：
文献类型：
--
作者：
N. Yılmaz;O. Aydin;A. Yeğin;A. Tiltak;E. Eren
研究目的：有强有力的证据表明偏头痛与多种共病疾病有关，包括心血管疾病和中风，其中氧化应激似乎是一个重要的潜在机制。本研究的目的是调查偏头痛患者的身体氧化/抗氧化平衡和对氧磷酶活性作为HDL功能的量度。对62名偏头痛患者和50名健康对照者的血清中的对氧磷酶和芳香酯酶活性进行了检测，同时检测了总氧化状态和抗氧化状态（p = 0.0065），而总氧化状态较高的患者相比，对照组（p = 0.0035）。ConclusionsThis初步研究表明，氧化/抗氧化平衡转向偏头痛的氧化状态。此外，结果还表明，芳基酯酶活性下降可能与HDL相关的功能障碍。
ObjectivesThere is strong evidence associating migraine with a variety of comorbid disorders, including cardiovascular disease and stroke, in which oxidative stress seems to be an important underlying mechanism. The aim of the study was to investigate in migraineurs the body oxidant/antioxidant balance and paraoxonase enzyme activities as a measure of HDL functionality.Design and methodsOxidative stress index, total oxidant status and antioxidant status were examined in addition to the paraoxonase and arylesterase enzyme activities in sixty-two migraineurs and fifty healthy control subjects.ResultsSerum arylesterase activities were significantly lower in migraineurs (p = 0.0065), whereas total oxidant status was higher in patients compared to the controls (p = 0.0035).ConclusionsThis preliminary study showed that oxidative/antioxidative balance shifted towards the oxidative status in migraine. Moreover, the results also suggested that decreased arylesterase activities might be associated with HDL-related disfunction.
人血清对氧磷酶/芳酯酶多态性。
影响因子：
9.8
作者：
Eckerson,HW;Wyte,CM;LaDu,BN
通讯作者：
LaDu,BN