Cyclic-di-GMP Reaches Out into the Bacterial RNA World
Cyclic-di-GMP Reaches Out into the Bacterial RNA World
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DOI：
10.1126/scisignal.3149pe44
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发表时间：
2010-11-23
影响因子：
7.3
通讯作者：
Hengge, Regine
中科院分区：
文献类型：
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作者：
Hengge, Regine
普遍存在的细菌信号分子双-(3'-5')-环鸟苷单磷酸 (c-di-GMP) 将第二信使信号重新提上分子微生物学家的议程。这不仅是因为它在促进生物膜形成方面的一般作用，而且还因为 c-di-GMP 结合的效应分子和受影响的目标过程日益多样化。效应器包括直接与复杂细胞机器相互作用的多种转录因子和蛋白质，以及充当核糖开关来调节转录延伸或翻译的RNA分子。 c-di-GMP 作用的这种灵活性使其能够控制细菌细胞中的多种分子过程。新证据进一步扩展了这一范围，包括与自剪接内含子相连的c-di-GMP核糖开关，该内含子已被其载体、致病菌艰难梭菌“驯化”，以控制下游基因的表达。
The ubiquitous bacterial signaling molecule bis-(3'-5')-cyclic guanosine monophosphate (c-di-GMP) has brought second messenger signaling back onto the agenda of molecular microbiologists. This is due not only to its general role in promoting biofilm formation, but also to the increasingly diverse array of effector molecules bound by c-di-GMP and of the target processes affected. Effectors include diverse transcription factors and proteins that directly interact with complex cellular machineries, as well as RNA molecules that act as riboswitches to regulate transcriptional elongation or translation. This flexibility in c-di-GMP action enables it to control diverse molecular processes in bacterial cells. New evidence further extends this range to include a c-di-GMP riboswitch linked to a self-splicing intron that has been "domesticated" by its carrier, the pathogenic bacterium Clostridium difficile, to serve in the control of expression of a downstream gene.