The expression ratio of Map7/B2M is prognostic for survival in patients with stage II colon cancer
The expression ratio of Map7/B2M is prognostic for survival in patients with stage II colon cancer
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DOI：
10.3892/ijo_00000043
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发表时间：
2008-09-01
影响因子：
5.2
通讯作者：
Mitas, Michael
中科院分区：
文献类型：
--
作者：
Blum, Craig;Graham, Amanda;Mitas, Michael
Colorectal cancer (CRC) is the second most frequent cause of cancer-related death in the United States. To determine whether certain molecular markers might be prognostic for survival, we measured by quantitative real-time RT-PCR the expression levels of 15 previously studied genes that are known to be up-regulated or down-regulated in the progression of epithelial cancers. The tumor samples were extracted from formalin-fixed paraffin-embedded primary tissues derived from patients with Stage 11 CRC who developed disease recurrence within two years (n=10), or were disease-free for at least 4 years (n=12). We were able to determine, by AUC curve analysis, that the ratio of microtubule associated protein 7 (Map7)/B2M was predictive of outcome in our sample set. Further, using Kaplan-Meier survival analysis, we observed significantly different curves as a function of marker positivity for the Map7/B2M (p=0.0001; HR=11) expression ratio. This suggests that the expression ratio of Map7/B2M may serve as a valuable prognostic marker in patients with Stage II colon cancer, and potentially guide therapeutic decision making.
