Atomic force microscope infrared spectroscopy of griseofulvin nanocrystals.
Atomic force microscope infrared spectroscopy of griseofulvin nanocrystals.
复制标题
DOI：
10.1021/ac4025889
复制
发表时间：
2013-12-03
影响因子：
7.4
通讯作者：
Tayor, Lynne S.
中科院分区：
文献类型：
--
作者：
Harrison, Aaron J.;Bilgili, Ecevit A.;Beaudoin, Stephen P.;Tayor, Lynne S.
这项工作的目的是评估光热诱导共振 (PTIR) 测量嵌入固体基质中的结晶有机药物纳米颗粒的局部红外吸收光谱的能力。在此，描述了亚 100 nm 有机晶体的化学表征的第一份报告；获得了 90 nm 灰黄霉素颗粒的红外光谱，证实了 PTIR 的化学分辨率超出了衍射极限。此外，通过动态光散射和 PTIR 图像分析得出的粒径分布相似，表明 PTIR 测量并未受到该系统不均匀红外吸收率的显着影响。因此，随着医疗应用越来越强调通过微/纳米工程结构进行局部药物输送，PTIR 可用于在这些长度尺度上明确地化学表征药物制剂。
The goal of this work was to evaluate the ability of photothermal induced resonance (PTIR) to measure the local infrared absorption spectra of crystalline organic drug nanoparticles embedded within solid matrices. Herein, the first reports of the chemical characterization of sub-100 nm organic crystals are described; infrared spectra of 90 nm griseofulvin particles were obtained, confirming the chemical resolution of PTIR beyond the diffraction limit. Additionally, particle size distributions via dynamic light scattering and PTIR image analysis were found to be similar, suggesting that the PTIR measurements are not significantly affected by inhomogeneous infrared absorptivity of this system. Thus as medical applications increasingly emphasize localized drug delivery via micro/nano-engineered structures, PTIR can be used to unambiguously chemically characterize drug formulations at these length scales.
登录
查看更多内容
影响因子：
3.3
作者：
Levenson, Erika;Lerch, Philippe;Martin, Michael C.
通讯作者：
Martin, Michael C.
DOI：
10.1039/jr9620001292
发表时间：
1962-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY
影响因子：
--
作者：
PAGE, JE;STANIFORTH, SE
通讯作者：
STANIFORTH, SE
影响因子：
5.8
作者：
Sievens-Figueroa, Lucas;Bhakay, Anagha;Dave, Rajesh N.
通讯作者：
Dave, Rajesh N.
影响因子：
5.2
作者：
Bhakay, Anagha;Dave, Rajesh;Bilgili, Ecevit
通讯作者：
Bilgili, Ecevit
影响因子：
7.4
作者：
Katzenmeyer, Aaron M.;Aksyuk, Vladimir;Centrone, Andrea
通讯作者：
Centrone, Andrea