Yersinia arthritis, immune functions and histocompatibility antigens.
Yersinia arthritis, immune functions and histocompatibility antigens.
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耶尔森氏菌关节炎、免疫功能和组织相容性抗原。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
O. Laitinen
中科院分区：
文献类型：
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作者：
H. Repo;M. Leirisalo;M. Gripenberg;S. Koskimies;S. Kontiainen;O. Laitinen
Secondary immune response to tetanus toxoid (TT), monocyte function, and generation of suppressor cells were studied in patients with previous yersinia arthritis (YA) and healthy controls. A comparison of HLA-B27 positive and negative subjects revealed that leukocytes from the former showed significantly higher responses to TT but not to a variety of other antigens in a lymphocyte proliferation test, and higher rates of migration in a leukocyte migration inhibition assay in the absence of TT. The enhanced migration of leukocytes supports the concept that hyper-reactive neutrophils contribute to inflammatory symptoms in HLA-B27 positive subjects, irrespective of previous YA. No correlation was found between HLA-DR specificities and YA. However, HLA-DR2/HLA-B7 was associated with high suppressor cell activity and low serum levels of anti-TT-antibodies. This accords with the view that HLA-DR antigens play a role in the regulation of immune response.
