Control of germ cell differentiation in Caenorhabditis elegans.
Control of germ cell differentiation in Caenorhabditis elegans.
复制标题
秀丽隐杆线虫生殖细胞分化的控制。
DOI：
10.1002/9780470514573.ch10
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Kimble,J
中科院分区：
文献类型：
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作者：
Ellis,RE;Kimble,J
秀丽隐杆线虫的生殖细胞系呈线性排列，最远端的生殖细胞仍处于有丝分裂状态，中间的生殖细胞进入减数分裂，近端的生殖细胞分化为精子或卵母细胞。两种信号转导途径控制生殖细胞的命运。GLP-1基因介导促进有丝分裂的信号，性别决定途径的基因介导决定生殖细胞是否发育为精子或卵母细胞的信号。来自这些通路的信息通过末端调节剂作用以指定细胞命运。例如，fog-1和fog-3是启动精子发生所必需的，而gld-1似乎是启动卵子发生所必需的。对这些终端调节器的研究表明，关于性别认同和有丝分裂的决定在生殖细胞中是联系在一起的。我们提出了一个三方的相互作用，迫使生殖细胞采取只有三种命运之一有丝分裂，精子发生或卵子发生。
The germline ofCaenorhabditis elegansis organized in a linear fashion—the most distal germ cells remain in mitosis, those in the middle enter meiosis and proximal cells differentiate as sperm or oocytes. Two signal transduction pathways control germ cell fates. Theglp‐1gene mediates a signal that promotes mitosis and the genes of the sex determination pathway mediate a signal that determines if germ cells will develop as sperm or oocytes. Information from these pathways acts through terminal regulators to specify cell fate. For example,fog‐1andfog‐3are required to initiate spermatogenesis andgld‐1appears to be required to initiate oogenesis. Study of these terminal regulators suggests that the decisions about sexual identity and mitosis are linked in germ cells. We propose a tripartite interaction that forces germ cells to adopt one of only three fates—mitosis, spermatogenesis or oogenesis.