Bone mineral lies mainly outside collagen fibrils: Predictions of a composite model for osteonal bone
Bone mineral lies mainly outside collagen fibrils: Predictions of a composite model for osteonal bone
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DOI：
10.1016/0021-9290(95)00147-6
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发表时间：
1996-07-01
影响因子：
2.4
通讯作者：
Turner, CH
中科院分区：
文献类型：
--
作者：
Pidaparti, RMV;Chandran, A;Turner, CH
我们提出，骨的弹性特性可以精确地建模为简单的纤维增强复合材料，前提是超微结构的矿物和胶原相的准确特性是可用的。用声学显微镜测量犬股骨前象限的离轴刚度系数，从纵向到横向以10度的增量测量。这些测量的分辨率约为60 μ m或小于一个骨的半径。随后将骨标本脱矿，并重复离轴测量以确定骨胶原的弹性。骨胶原纤维主要不是沿骨长轴排列，而是与骨长轴呈30度排列。基于实验数据建立了简单的复合模型。最适合实验数据的模型假设：(1)骨胶原蛋白与骨长轴呈30度排列，(2)75%的矿物晶体位于胶原原纤维外，(3)胶原原纤维外的矿物晶体的c轴在纵向。版权所有爱思唯尔科学有限公司
We propose that the elastic properties of osteonal bone can be modeled accurately as a simple fiber-reinforced composite, provided that accurate properties for the mineral and collagen phases of the ultrastructure are available. Off-axis stiffness coefficients were measured in anterior quadrant of canine femora at 10 degrees increments from longitudinal to transverse direction using an acoustic microscope. The resolution of these measurements was about 60 mu m or less than the radius of one osteon. The bone specimens were subsequently demineralized and the off-axis measurements were repeated to determine the elasticity of bone collagen. Bone collagen fibrils were not principally aligned along the long axis of the bone, but demonstrated an alignment that was 30 degrees from the long axis. A simple composite model was developed based on the experimental data. The model that best fit experimental data assumed that (1) bone collagen was aligned 30 degrees from the long axis of the bone, (2) 75% of mineral crystals reside outside of collagen fibrils, and (3) mineral crystals outside of collagen fibrils have their c-axis in the longitudinal direction. Copyright (C) 1996 Elsevier Science Ltd.