CORRELATION OF EXPRESSION OF H/LE(Y)/LE(B) ANTIGENS WITH SURVIVAL IN PATIENTS WITH CARCINOMA OF THE LUNG
CORRELATION OF EXPRESSION OF H/LE(Y)/LE(B) ANTIGENS WITH SURVIVAL IN PATIENTS WITH CARCINOMA OF THE LUNG
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DOI：
10.1056/nejm199207023270103
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发表时间：
1992-07-02
影响因子：
158.5
通讯作者：
HAKOMORI, S
中科院分区：
文献类型：
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作者：
MIYAKE, M;TAKI, T;HAKOMORI, S
背景资料。H/Le(Y)/Le(B)抗原在不同组织类型肺癌中的高表达可能与A、B血型抗原缺失有关。我们评估了这种可由单抗MIA-15-5定义的抗原表达可能具有预后价值的可能性，正如我们先前观察到的MIA-15-5抑制肿瘤细胞运动和转移所提示的那样。我们使用MIA-15-5对149例有良好临床病理记录的原发性肺癌患者的组织切片进行染色。比较肿瘤染色阳性患者的生存曲线和肿瘤染色阴性患者的生存曲线。采用COX比例风险回归模型进行多因素分析。在所研究的149例患者中，91例MIA阳性肿瘤患者的5年生存率显著低于58例MIA阴性肿瘤患者的5年生存率(20.9%vs.58.6%，P
Background. The level of expression of H/Le(y)/Le(b) antigens is high in various histologic types of lung cancer, a feature that may be related to deletion of A and B blood-group antigens. We evaluated the possibility that expression of this antigen, which can be defined by the monoclonal antibody MIA-15-5, might be of prognostic value, as suggested by our previous observation that MIA-15-5 inhibits tumor-cell motility and metastasis.Methods. We used MIA-15-5 to stain tissue sections from 149 patients with primary lung cancer whose clinico-pathological histories were well documented. The survival curves for patients whose tumors stained positively were compared with the curves for those whose tumors stained negatively. Multivariate analyses were performed with a Cox proportional-hazards regression model.Results. Among the 149 patients studied, five-year survival in the 91 patients with MIA-positive tumors was significantly lower than survival in the 58 with MIA-negative tumors (20.9 percent vs. 58.6 percent, P