HYPERTONIC SALINE IS A NEGATIVE INOTROPIC AGENT IN NORMOVOLUMIC DOGS
HYPERTONIC SALINE IS A NEGATIVE INOTROPIC AGENT IN NORMOVOLUMIC DOGS
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DOI：
10.1152/ajpheart.1994.267.2.h667
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发表时间：
1994-08-01
影响因子：
--
通讯作者：
BINKLEY, PF
中科院分区：
文献类型：
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作者：
CONSTABLE, PD;MUIR, WW;BINKLEY, PF
在容量正常、氯醛糖麻醉、完整（n = 14）和血管阻断（n = 8）的犬中测定了高渗盐水（HS）和高渗葡萄糖（HD; 2，400 mosmol/l，4 ml/kg）的变力作用。静脉输注溶液3分钟。HS和HD迅速增加了完整和自主阻滞犬的前负荷，通过血浆容量、舒张末期容量和舒张末期压的显着增加（P < 0.05）来评估。在正常犬中，HS导致收缩末期弹性（E（es））无显著性降低，左心室压力（dP/dt（max））和心输出量的最大变化率无显著性增加，而HD导致E（es）、dP/dt（max）和心输出量显著增加。在心脏阻断犬中，HS显著降低E（es），显著增加dP/dt（max），但不改变心输出量，而HD显著增加E（es），dP/dt（max）和心输出量。我们的结论是，在正常容量的动物，HS是一个负性肌力药物，HD是一个正性肌力药物，和在体内的作用离子高渗剂（HS）的非离子高渗剂（HD）的不同。
The inotropic effects of hypertonic saline (HS) and hyperosmotic dextrose (HD; 2,400 mosmol/l, 4 ml/kg) were determined in normovolumic, chloralose-anesthetized, intact (n = 14) and autonomically blocked (n = 8) dogs. Solutions were infused intravenously over 3 min. HS and HD rapidly increased preload in both intact and autonomically blocked dogs, as assessed by significant (P < 0.05) increases in plasma volume, end-diastolic volume, and end-diastolic pressure. In intact dogs, HS produced a nonsignificant decrease in end-systolic elastance (E(es)) and a nonsignificant increase in the maximal rate of change of left ventricular pressure (dP/dt(max)) and cardiac output, whereas HD produced a significant increase in E(es), dP/dt(max), and cardiac output. In autonomically blocked dogs, HS significantly decreased E(es) and significantly increased dP/dt(max) but did not alter cardiac output, whereas HD significantly increased E(es), dP/dt(max), and cardiac output. We conclude that in normovolumic animals, HS is a negative inotropic agent, HD is a positive inotropic agent, and the in vivo effect of an ionic hyperosmotic agent (HS) differs from that of a nonionic hyperosmotic agent (HD).