Magnetic resonance imaging detects significant sex differences in human myocardial strain.
Magnetic resonance imaging detects significant sex differences in human myocardial strain.
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DOI：
10.1186/1475-925x-10-76
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发表时间：
2011-08-22
影响因子：
3.9
通讯作者：
Pasque MK
中科院分区：
文献类型：
--
作者：
Lawton JS;Cupps BP;Knutsen AK;Ma N;Brady BD;Reynolds LM;Pasque MK
导致男性和女性心脏病患者之间显着结果差异的病理生理学在很大程度上尚不清楚。需要进一步研究两性之间基本的心脏生理差异。本研究利用基于磁共振成像 (MRI) 的多参数应变分析来寻找局部心肌收缩功能的性别差异。收缩末期应变（周向、纵向和径向）是根据 60 名正常成年志愿者（32 名女性）中每人基于 MRI 的射频组织标记网格点位移插值得到的。正常女性志愿者 (n = 32) 的平均整体左心室 (LV) 应变的绝对值（功能更好）显着大于正常男性志愿者 (n = 28)，无论是在圆周方向（男性/女性 = -0.19 ± 0.02 对比 -0.21 ± 0.02；p = 0.025）还是纵向（男性/女性 = -0.14 ± 0.03 对比）。 -0.16 ± 0.02；p = 0.007)。正常女性志愿者中左心室周向和纵向应变显着较大的发现表明，两性之间的基线收缩差异可能导致心血管疾病结果的众所周知的差异。需要进一步的工作来确定女性和男性在心血管疾病发作时左心室应变发生的病理变化。
The pathophysiology responsible for the significant outcome disparities between men and women with cardiac disease is largely unknown. Further investigation into basic cardiac physiological differences between the sexes is needed. This study utilized magnetic resonance imaging (MRI)-based multiparametric strain analysis to search for sex-based differences in regional myocardial contractile function. End-systolic strain (circumferential, longitudinal, and radial) was interpolated from MRI-based radiofrequency tissue tagging grid point displacements in each of 60 normal adult volunteers (32 females). The average global left ventricular (LV) strain among normal female volunteers (n = 32) was significantly larger in absolute value (functionally better) than in normal male volunteers (n = 28) in both the circumferential direction (Male/Female = -0.19 ± 0.02 vs. -0.21 ± 0.02; p = 0.025) and longitudinal direction (Male/Female = -0.14 ± 0.03 vs. -0.16 ± 0.02; p = 0.007). The finding of significantly larger circumferential and longitudinal LV strain among normal female volunteers suggests that baseline contractile differences between the sexes may contribute to the well-recognized divergence in cardiovascular disease outcomes. Further work is needed in order to determine the pathologic changes that occur in LV strain between women and men with the onset of cardiovascular disease.