Clinical guidelines for the management of treatment-resistant depression: French recommendations from experts, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental
Clinical guidelines for the management of treatment-resistant depression: French recommendations from experts, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental
复制标题
DOI：
10.1186/s12888-019-2237-x
复制
发表时间：
2019-08-28
期刊：
影响因子：
4.4
通讯作者：
Haffen, E.
中科院分区：
文献类型：
--
作者：
Bennabi, L. D.;Charpeaud, T.;Haffen, E.
背景对于重度抑郁症无反应者的连续抗抑郁药物治疗指南尚不明确。方法基于RAND/UCLA的适宜性方法，法国生物精神病学和神经精神药理学协会和基金会制定了治疗难治性抑郁症的专家共识指南。专家指南结合了科学证据和专家临床医生的意见，为难治性抑郁症提出了建议。一份包含118个与高度详细的临床表现有关的问题的书面调查由36名严重抑郁症及其治疗领域的精神病学家专家完成，调查的风险-收益范围从0到9不等。结果这些指南的范围包括对药物耐药性和耐药风险的评估，以及对严重抑郁症的药物和心理策略。结论专家共识指南将有助于参与日常评估和管理多种常见和复杂临床情况的难治性抑郁症的临床医生的治疗决策。
BackgroundClear guidance for successive antidepressant pharmacological treatments for non-responders in major depression is not well established.MethodBased on the RAND/UCLA Appropriateness Method, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental developed expert consensus guidelines for the management of treatment-resistant depression. The expert guidelines combine scientific evidence and expert clinicians' opinions to produce recommendations for treatment-resistant depression. A written survey comprising 118 questions related to highly-detailed clinical presentations was completed on a risk-benefit scale ranging from 0 to 9 by 36 psychiatrist experts in the field of major depression and its treatments. Key-recommendations are provided by the scientific committee after data analysis and interpretation of the results of the survey.ResultsThe scope of these guidelines encompasses the assessment of pharmacological resistance and situations at risk of resistance, as well as the pharmacological and psychological strategies in major depression.ConclusionThe expert consensus guidelines will contribute to facilitate treatment decisions for clinicians involved in the daily assessment and management of treatment-resistant depression across a number of common and complex clinical situations.