Aminergic modulation of glycine release in a spinal network controlling swimming in Xenopus laevis
Aminergic modulation of glycine release in a spinal network controlling swimming in Xenopus laevis
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DOI：
10.1111/j.1469-7793.1997.111bi.x
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发表时间：
1997-08-15
影响因子：
5.5
通讯作者：
Sillar, KT
中科院分区：
文献类型：
--
作者：
McDearmid, JR;ScrymgeourWedderburn, JF;Sillar, KT
1.神经调质可以通过突触前控制递质释放来加强或减弱神经元之间的突触，从而影响神经网络功能的变化。我们研究了两种生物胺对非洲爪蟾蝌蚪脊髓节律发生器抑制性连接的影响。甘氨酸能抑制电位发生在游泳活动的运动神经元周期中期减少5-羟色胺（5-HT;血清素）和增强去甲肾上腺素（NA）。这些对抑制性突触强度的相反作用是在突触前介导的，其中5-HT减少而Nrl增加甘氨酸从抑制性末端释放的可能性。胺对游泳也有相反的影响：5-HT增加运动爆发持续时间，而NA降低游泳频率甘氨酸能传输mag的Amergic调制，从而控制游泳的基本参数，并迫使脊髓网络产生其可能输出频谱的相反极端。
1. Neuromodulators can effect changes in neural network function by strengthening or weakening synapses between neurons via presynaptic control of transmitter release. We have examined the effects of two biogenic amines on inhibitory connections of a spinal rhythm generator in Xenopus tadpoles.2. Glycinergic inhibitory potentials occurring mid-cycle in motoneurons during swimming activity are reduced by 5-hydroxytryptamine (5-HT; serotonin) and enhanced by noradrenaline (NA). These opposing effects on inhibitory synaptic strength are mediated presynaptically where 5-HT decreases and Nrl increases the probability of glycine release from inhibitory terminals.3. The amines also have contrasting effects on swimming: 5-HT increased motor burst durations while NA reduced swimming frequency Aminergic modulation of glycinergic transmission mag thus control fundamental parameters of swimming and force the spinal network to generate opposite extremes of its spectrum of possible outputs.