Alexithymia correlates with the size of the right anterior Cingulate
Alexithymia correlates with the size of the right anterior Cingulate
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DOI：
10.1097/01.psy.0000097348.45087.96
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发表时间：
2004-01-01
影响因子：
3.3
通讯作者：
Pujol, J
中科院分区：
文献类型：
--
作者：
Gündel, H;López-Sala, A;Pujol, J
目的：作者研究了扣带回前部形态学的个体间差异与述情障碍之间的可能关系。材料和方法：100名健康大学毕业生（51名女性，49名男性;平均年龄25.6岁）的磁共振图像。在重新格式化的矢状面视图上测量两个半球的ACG表面积。采用多伦多述情障碍量表（TAS-20）和气质与性格量表（TCI）进行评定。结果：男性（r = 0.37; p = 0.009）和女性（r = 0.30; p = 0.034）的右侧ACG表面积与TAS-20总分显著相关。在控制三个TCI子量表（伤害回避、自我导向和自我超越）后，TAS-20总ACG和右侧ACG之间的相关性在女性中变得不显著，但在男性中仅略微降低（r = 0.32; p = 0.032）。以右侧ACG为因变量的线性回归模型显示，脑容量、TCI-伤害回避和TAS 20总分是总样本中的显著预测因子（总变异解释比例（EPTV）37%）。在男性中，除脑容量外，只有TAS-20总分显示出高度显著的贡献（EPTV 41%），而在女性中，只有TCI伤害回避是一个显著的预测因子（EPTV 36%）。结论：作者的研究结果表明，在健康受试者中，用TAS测量的右侧ACG的大小与述情障碍之间存在显著的正相关。这尤其适用于男性，而在女性中，ACG大小与TCI的子量表伤害避免更相关。我们的研究结果还表明，人类的情绪处理，特别是消极情绪的部分偏侧化。
Objective: The authors investigated a possible relationship between interindividual variability in anterior cingulate gyrus (ACG) morphology and alexithymia. Materials and Methods: Magnetic resonance images were obtained in 100 healthy university graduates (51 female, 49 male; mean age 25.6 y). Surface area measurements of the ACG were performed on reformatted sagittal views in both hemispheres. The Toronto Alexithymia Scale (TAS-20) and the Temperament and Character Inventory (TCI) were administered. Results: Right ACG surface area significantly correlated with TAS-20 total score in men (r = 0.37; p = 0.009) and in women (r = 0.30; p = 0.034). After controlling for three TCI subscales (harm avoidance, self-directedness, and self-transcendency), the correlation between TAS-20 total and right ACG became nonsignificant in women, but was only slightly reduced (r = 0.32; p = 0.032) in men. A linear regression model with right ACG as a dependent variable revealed brain volume, TCI-harm avoidance and TAS 20 total score as significant predictors in the total sample (explained proportion of total variation (EPTV) 37%). In men, beside brain volume, only TAS-20 total score showed a highly significant contribution (EPTV 41%), whereas in women only TCI-harm avoidance was a significant predictor (EPTV 36%). Conclusions: The authors' findings indicate that there is a significant positive relation between the size of the right ACG and alexithymia as measured with the TAS in healthy subjects. This applies especially for men whereas in women ACG size is more associated with the subscale harm avoidance of the TCI. Our findings also suggest a partial lateralization of human emotion processing, especially negative emotion.