Integrated Concentration of Growth Hormone in Juvenile-onset Diabetes
Integrated Concentration of Growth Hormone in Juvenile-onset Diabetes
复制标题
青少年发病糖尿病中生长激素的综合浓度
DOI：
10.2337/diab.29.5.391
复制
发表时间：
1980
期刊：
影响因子：
7.7
通讯作者：
R. G. Thompson
中科院分区：
文献类型：
--
作者：
J. T. Hayford;M. Danney;J. A. Hendrix;R. G. Thompson
在对 42 名青少年发病糖尿病受试者进行的 50 项研究中，对血浆生长激素浓度的 24 小时模式进行了评估。在受试者保持走动并维持日常饮食和胰岛素治疗方案的条件下，使用便携式蠕动泵在 24 小时内连续采集血液样本。所有糖尿病患者都表现出以生长激素分泌频繁为特征的昼夜模式。青少年发病的糖尿病患者的生长激素平均 24 小时浓度（称为综合浓度）显着高于年龄和性别匹配的非糖尿病人群（P < 0.001）。 20 岁以下的青少年发病糖尿病患者的生长激素综合浓度显着高于年龄较大的青少年发病糖尿病患者（P < 0.005）。葡萄糖和生长激素的综合浓度之间不存在统计学上显着的相关性；因此，该研究未能为我们的假设提供支持，即糖尿病患者生长激素浓度升高是高血糖的结果。青少年发病的糖尿病患者的每日血糖浓度变异性与生长激素综合浓度呈正相关（P < 0.015）。我们的观察表明，血浆葡萄糖浓度的快速下降或绝对低血糖的发作是重要因素，导致糖尿病人群中观察到的生长激素的综合浓度升高和分泌激增。
Twenty-four-hour patterns of plasma growth hormone concentrations were evaluated during 50 studies of 42 subjects with juvenile-onset diabetes mellitus. Blood was sampled continuously over 24 h using a portable peristaltic pump under conditions in which subjects remained ambulatory and maintained their daily dietary and insulin regimens. All diabetics showed diurnal patterns characterized by frequent episodes of secretion of growth hormone. The mean 24-h concentration of growth hormone, designated the integrated concentration, was significantly higher among juvenile-onset diabetics (P < 0.001) than it was in ageand sex-matched nondiabetic populations. Juvenileonset diabetics younger than 20 yr had significantly higher (P < 0.005) growth hormone integrated concentrations than did older juvenile-onset diabetics. There was no statistically significant correlation between the integrated concentrations of glucose and growth hormone; thus, the study failed to provide us with support for the hypothesis that elevated growth hormone concentrations in diabetics are a consequence of hyperglycemia. Variability of diurnal glucose concentrations was positively correlated (P < 0.015) with the growth hormone integrated concentration among juvenile-onset diabetics. Our observations indicate that rapid declines in plasma glucose concentration or episodes of absolute hypoglycemia were significant factors, contributing to both the elevated integrated concentration and the secretory spiking of growth hormone observed in the diabetic population,