There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases.
There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases.
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DOI：
10.1016/j.tins.2016.01.008
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发表时间：
2016-03
影响因子：
15.9
通讯作者：
Miller CCJ
中科院分区：
文献类型：
--
作者：
Paillusson S;Stoica R;Gomez-Suaga P;Lau DHW;Mueller S;Miller T;Miller CCJ
阿尔茨海默病（AD）、帕金森病（PD）和肌萎缩侧索硬化症伴额颞叶痴呆（ALS/FTD）是目前无法治愈的主要神经退行性疾病。所有这些疾病的特点都是对几个看似不同的细胞过程造成损害。这种损伤的广泛性使得理解致病机制和设计新的治疗方法变得困难。不同的受损功能是否可以在一个共同的疾病途径中联系在一起？哪些受损功能应该作为治疗的目标？神经退行性疾病中受损的许多功能是由线粒体与内质网的一个特殊区域（ER；线粒体相关ER膜或MAM）的通讯调节的。此外，最近的几项研究表明，er -线粒体接触的紊乱发生在神经退行性疾病中。在这里，我们回顾一下这些发现。线粒体和内质网形成密切的物理接触。er -线粒体接触调节神经退行性疾病中受损的功能。内质网线粒体接触在神经退行性疾病中受损。
Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with associated frontotemporal dementia (ALS/FTD) are major neurodegenerative diseases for which there are no cures. All are characterised by damage to several seemingly disparate cellular processes. The broad nature of this damage makes understanding pathogenic mechanisms and devising new treatments difficult. Can the different damaged functions be linked together in a common disease pathway and which damaged function should be targeted for therapy? Many functions damaged in neurodegenerative diseases are regulated by communications that mitochondria make with a specialised region of the endoplasmic reticulum (ER; mitochondria-associated ER membranes or ‘MAM’). Moreover, several recent studies have shown that disturbances to ER–mitochondria contacts occur in neurodegenerative diseases. Here, we review these findings. Mitochondria and the ER form close physical contacts. ER–mitochondria contacts regulate functions damaged in neurodegenerative diseases. ER–mitochondria contacts are damaged in neurodegenerative diseases.