CD10+ CELL-POPULATION IN THE BONE-MARROW OF PATIENTS WITH ADVANCED NEUROBLASTOMA
CD10+ CELL-POPULATION IN THE BONE-MARROW OF PATIENTS WITH ADVANCED NEUROBLASTOMA
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DOI：
10.1002/mpo.2950220210
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
RAMOT, B
中科院分区：
文献类型：
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作者：
MANDEL, M;RECHAVI, G;RAMOT, B
骨髓的免疫细胞学分析可以提供神经母细胞瘤的临床有用的预后信息。在用一组单克隆抗体分析骨髓时，我们发现两名婴儿患有IV-S期神经母细胞瘤，其骨髓中含有大量常见的急性淋巴细胞白血病（ALL）样细胞，这些单克隆抗体可检测成神经细胞和其他定义性B、T和骨髓谱系。该群体表达HLA-DR、CD 19（B1）、CD 10（CALLA），偶尔表达CD 20（B1）。自1988年以来，我们又研究了17例晚期神经母细胞瘤（IV-S，III和IV）。在19例患者中的10例中，骨髓显示CD 10群体扩增（20-70%）。这类患者的预后较好。在9名没有扩增的CD 10群体的患者中，8名在诊断后9个月内死亡，而在10名具有扩增的CD 10群体的患者中，仅1名死亡，其他人在诊断后6-30个月内存活（P < 0.001）。因此，播散性神经母细胞瘤患者骨髓中CD 10的扩增可能是一个预后因素。除了单个患者中这一特定人群的预后价值外，它的存在可能揭示免疫系统和神经内分泌区室之间的相互关系。(C)1994 Wiley-Liss，Inc.
Immunocytologic analyses of bone marrow can provide clinically useful prognostic information in neuroblastoma. While analyzing the bone marrow with a panel of monoclonal antibodies, which detect neuroblasts and other defining B-, T-, and myloid lineage, we identified two infants with stage IV-S neuroblastoma whose bone marrow contained a large population of common acute lymphoblastic leukemia (ALL)-like cells. This population expressed HLA-DR, CD19(B1), CD10(CALLA), and occasionally CD20(B1). Since 1988,17 additional patients with advanced neuroblastoma (IV-S, III, and IV) were studied by us. In 10 of the 19 patients, the bone marrow revealed an expanded CD10 population (20-70%). It appears that this group of patients has a better prognosis. Out of 9 patients who did not have an expanded CD10 population, 8 died within 9 months from diagnosis, whereas out of 10 patients with an expanded CD10 population only one died and the others are alive, 6-30 months from diagnosis (P < 0.001). An expanded CD10 population in the bone marrow of disseminated neuroblastoma patients may therefore serve as a prognostic factor. Apart from the prognostic value of this particular population in the single patient, its presence may shed light on the interrelationship between the immune system and the neuroendocrine compartment. (C) 1994 Wiley-Liss, Inc.