Nimodipine tested in a human model of cerebral ischaemia
Nimodipine tested in a human model of cerebral ischaemia
复制标题
尼莫地平在人类脑缺血模型中进行测试
DOI：
10.1007/bf00315133
复制
发表时间：
2004
影响因子：
2.9
通讯作者：
J. Hesselink
中科院分区：
文献类型：
--
作者：
V. Kraaier;A. Huffelen;G. Wieneke;J. Hesselink
尼莫地平30 mg和60 mg t.i.d.已经在一项双盲、安慰剂对照、交叉研究中进行了测试，该研究基于使用过度通气来降低脑动脉中的流速。研究了抗缺血特性是否是由于对脑血管的血管舒张作用或对脑神经元的抗缺血作用。有轻微的心血管效应，静息时EEG无任何显著变化。在标准化过度通气期间，尼莫地平组和安慰剂组的血流速度降低没有差异（分别为56%、56%和59%）。两种剂量的尼莫地平，但是，显着衰减过度通气引起的增加缓慢的脑电图活动在1.5-6.0赫兹的范围。它的结论是，抗缺血性能的尼莫地平是由于对中枢神经系统的影响，而不是对脑血流的影响。
The anti-ischaemic properties of nimodipine 30 mg and 60 mg t.i.d. for 4 days has been tested in a double-blind, placebo-controlled, cross-over study based on the use of hyperventilation to reduce flow velocity in cerebral arteries. Whether the anti-ischaemic properties were due to a vasodilatator action on cerebral blood vessels or to an anti-ischaemic effect on cerebral neurons was studied. There was a slight cardiovascular effect, without any significant change in the EEG at rest. During standardized hyperventilation, there was no difference in the reduction in the blood flow velocity in the nimodipine and placebo groups (namely 56%, 56% and 59%). Both doses of nimodipine, however, significantly attenuated the hyperventilation-induced increase in slow EEG activity in the 1.5–6.0 Hz range. It is concluded that the anti-ischaemic properties of nimodipine are due to an effect on the central nervous system rather than to an effect on cerebral blood flow.