Fetal dynamic phase-contrast MR angiography using ultrasound gating and comparison with Doppler ultrasound measurements
Fetal dynamic phase-contrast MR angiography using ultrasound gating and comparison with Doppler ultrasound measurements
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DOI：
10.1007/s00330-018-5940-y
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发表时间：
2019-08-01
影响因子：
5.9
通讯作者：
de Sousa, M. Tavares
中科院分区：
文献类型：
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作者：
Schoennagel, B. P.;Yamamura, J.;de Sousa, M. Tavares
目的探讨采用与磁共振兼容的多普勒超声传感器（DUS）对胎儿降主动脉（AoD）进行期相对比(PC)-磁共振血管造影的可行性，并比较速度测量与多普勒超声测量的差异。方法在这项前瞻性研究中，使用磁共振兼容DUS在1.5T时对12例人类胎儿（平均胎龄32.8周）进行2D PC-MR血管造影。将胎儿AoD的峰值血流速度与当天进行的多普勒超声测量结果进行比较。通过在5个胎儿中重复PC-MR测试PC-MR测量的可重复性。结果使用DUS的所有胎儿均成功完成AoD动态PC-MR血管造影，平均胎心率为140bpm（范围129-163）。时间-速度曲线显示典型的动脉血流模式。PC-MR平均流速和平均通量分别为21.2cm/s（范围8.6-36.8）和8.4ml/s（范围3.2-14.6）。PC-MR平均通量和脑卒中容积与胎龄呈正相关（r=0.66, p=0.02和r=0.63, p=0.03）。PC-MR和多普勒超声峰值速度显示高度显著相关(r=0.8, p
ObjectivesTo investigate the feasibility of fetal phase-contrast (PC)-MR angiography of the descending aorta (AoD) using an MR-compatible Doppler ultrasound sensor (DUS) for fetal cardiac gating and to compare velocimetry with Doppler ultrasound measurements.MethodsIn this prospective study, 2D PC-MR angiography was performed in 12 human fetuses (mean gestational age 32.8weeks) using an MR-compatible DUS for gating of the fetal heart at 1.5T. Peak flow velocities in the fetal AoD were compared with Doppler ultrasound measurements performed on the same day. Reproducibility of PC-MR measurements was tested by repeated PC-MR in five fetuses.ResultsDynamic PC-MR angiography in the AoD was successfully performed in all fetuses using the DUS, with an average fetal heart rate of 140bpm (range 129-163). Time-velocity curves revealed typical arterial blood flow patterns. PC-MR mean flow velocity and mean flux were 21.2cm/s (range 8.6-36.8) and 8.4ml/s (range 3.2-14.6), respectively. A positive association between PC-MR mean flux and stroke volume with gestational age was obtained (r=0.66, p=0.02 and r=0.63, p=0.03). PC-MR and Doppler ultrasound peak velocities revealed a highly significant correlation (r=0.8, p