Compliance with cyclosporine in adolescent renal transplant recipients
Compliance with cyclosporine in adolescent renal transplant recipients
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DOI：
10.1007/s004670050335
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发表时间：
1997-10-01
影响因子：
3
通讯作者：
Koren, G
中科院分区：
文献类型：
--
作者：
Blowey, DL;Hebert, D;Koren, G
儿童不遵守规定的药物治疗方案是一个复杂的问题，人们对此知之甚少。我们测量了青少年肾移植人群中环孢素不依从性的程度和模式，并试图确定与依从性差相关的因素。在知情同意后，向每例患者提供装在药瓶中的环孢素胶囊，药瓶盖上装有电子监测装置（MEMS-4）。在24例合格患者中，19例患者（8例女性，11例男性）完成了研究。4例（21%）患者服用的环孢素剂量低于处方剂量的80%。5例（26%）患者休药期超过或等于3次连续给药。夜间给药依从性有改善趋势（88.5% vs. 93.4%，P = 0.09），研究期间依从性呈下降趋势（P = 0.17）。没有发现任何测试变量与不遵守有关。经验丰富的医生和护士能够识别出MEMS识别为不依从的4个人中的2个。此外，4例不依从的患者中有2例表现出较低的环孢素谷浓度（
Inadequate compliance with prescribed medication regimens in children is complex and poorly understood. We measured the extent and pattern of noncompliance with cyclosporine in our adolescent renal transplant population and attempted to determine factors associated with poor compliance. After informed consent, each patient was provided cyclosporine capsules in a medication bottle equipped with an electronic monitoring device (MEMS-4) in the lid. Of the 24 patients eligible, 19 patients (8 female, 11 male) completed the study. Four (21%) patients took less than 80% of the prescribed cyclosporine doses. Five (26%) patients took drug holidays involving greater than or equal to 3 consecutive doses. There was a trend towards improved compliance with the evening dose (88.5% vs. 93.4%, P = 0.09) and a downward trend in compliance over the course of the study (P = 0.17). None of the variables tested were found to be associated with noncompliance. Experienced physicians and nurses were able to identify 2 of the 4 individuals who were identified by MEMS as noncompliant. Additionally, 2 of the 4 noncompliant patients demonstrated low cyclosporine trough levels (