The Expansion of CD25 high IL-10 high FoxP3 high B Regulatory Cells Is in Association with SLE Disease Activity.
The Expansion of CD25 high IL-10 high FoxP3 high B Regulatory Cells Is in Association with SLE Disease Activity.
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DOI：
10.1155/2015/254245
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发表时间：
2015
影响因子：
4.1
通讯作者：
Toubi E
中科院分区：
文献类型：
--
作者：
Vadasz Z;Peri R;Eiza N;Slobodin G;Balbir-Gurman A;Toubi E
B调节细胞(Bregs)属于激活的B细胞亚群，任务是维持自身耐受和防止自身免疫。虽然它们有相似的调控机制，如IL-10依赖，但它们也不愿通过表达Fas-配体、转化生长因子-β和PDL-1来显示其抑制作用。在这项研究中，我们首次显示了系统性红斑狼疮患者CD25HighFoxP3高Bregs的扩增(18.5±3.052%比11.0±1.654%，p<；0.001)。这种扩大也被证明与SLE疾病活动性相关(r=0.75)。此外，CD25HighFoxP3High Bregs也高表达IL-10，并在信号素3A刺激下进一步扩增。综上所述，我们表明CD25HighFoxP3High是Bregs的一个附加亚型，参与调节SLE疾病的活动。IL-10的表达可能是SLE患者血清IL-10升高的原因之一。高血清IL-10与CD25HighFoxP3高Breg细胞的关系尚需进一步研究。
B regulatory cells (Bregs) belong to a subgroup of activated B cells tasked with maintaining self-tolerance and preventing autoimmunity. While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, and PDL-1. In this study we show, for the first time, the expansion of CD25highFoxP3high Bregs in systemic lupus erythematosus (SLE) patients compared to healthy individuals (18.5 ± 3.052% versus 11.0 ± 1.654%, p < 0.001, resp.). This expansion was also shown to correlate with SLE disease activity (r = 0.75). In addition, CD25highFoxP3high Bregs were also IL-10high expressing and further expanded when stimulated with semaphorin 3A. In sum we show that CD25highFoxP3high are an additional subtype of Bregs, involved in regulating SLE disease activity. Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients. Further studies are required in order to assess the relation between high serum IL-10 and CD25highFoxP3high Breg cells.