Phylogenetic Characterization Genome Segment 2 of Bluetongue Virus Strains Belonging to Serotypes 5, 7 and 24 Isolated for the First Time in China During 2012 to 2014
Phylogenetic Characterization Genome Segment 2 of Bluetongue Virus Strains Belonging to Serotypes 5, 7 and 24 Isolated for the First Time in China During 2012 to 2014
复制标题
2012-2014年国内首次分离的5、7、24血清型蓝舌病病毒株基因组片段2的系统发育特征
DOI：
10.1111/tbed.12479
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发表时间：
2017
影响因子：
4.3
通讯作者：
Li H.
中科院分区：
文献类型：
--
作者：
Yang H.;Xiao L.;Wang J.;Meng J.;Lv M.;Liao D.;Song J.;Gao L.;Xiong H.;He Y.;Niu B.;Chuang X.;Li H.
中国流行蓝舌病，1996年至1997年共分离到8种不同血清型(BTV-1、BTV-2、BTV-3、BTV-4、BTV-9、BTV-12、BTV-15和BTV-16)。然而，从那时起，BTV感染的流行病学调查就陷入了很长的停顿。2012-2014年间，在云南省和广东省首次从哨兵动物血液中分离到8株BTV，分别属于血清型5、7和24型。对这些中国BTV毒株的基因组片段2进行系统发育分析，将它们分别划分为E、F和A核型，并与同一血清型的参考毒株进行了比较。对于每个血清型，中国毒株紧密地聚集在一起，形成了中国的一个亚系。此外，这些毒株与非洲毒株的亲缘关系最近，表明它们可能与非洲毒株有最近的共同祖先。据我们所知，这是首次在东南亚分离到BTV-5、BTV-7和BTV-24毒株。这些资料将有助于了解北京地区蓝舌病的流行情况，改进中国及周边国家蓝舌病的诊断分析和控制措施。
Bluetongue is endemic in China, andBluetongue virus(BTV) strains belonging to eight different serotypes (BTV‐1, BTV‐2, BTV‐3, BTV‐4, BTV‐9, BTV‐12, BTV‐15 and BTV‐16) had been isolated between 1996 and 1997. However, there has been a long pause in investigating the epidemiology of BTV infection since then. During 2012–2014, eight BTV strains belonging to serotypes 5, 7 and 24 were isolated for the first time in Yunnan and Guangdong provinces from the blood of sentinel animals. Phylogenetic analyses of genome segment 2 of these Chinese BTV strains grouped them into nucleotypes E, F and A, respectively, along with the reference strains of the same serotype. For each serotype, Chinese strains cluster together closely to form a China's sublineage. In addition, these strains were most closely related to strains from Africa, indicating that they may share a recent common ancestry with African strains. To our knowledge, this is the first time that BTV‐5, BTV‐7 and BTV‐24 strains have been isolated in South‐East Asia. These data will be beneficial for understanding the BTV epidemiology and improving diagnostic assays and control measures against bluetongue in China and its neighbouring countries in the Asia–Pacific region.