Atypical cerebral laterality in adults with persistent developmental stuttering
Atypical cerebral laterality in adults with persistent developmental stuttering
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DOI：
10.1212/01.wnl.0000094320.44334.86
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发表时间：
2003-11-25
期刊：
影响因子：
9.9
通讯作者：
Heilman, KM
中科院分区：
文献类型：
--
作者：
Foundas, AL;Corey, DM;Heilman, KM
背景资料：在人类大脑中发现的两个最一致的解剖学不对称是右前额叶比左前额叶大，左枕叶比右枕叶大。这些区域的减少或逆转的不对称被认为是非典型大脑偏侧性的标志，并且非典型大脑偏侧性已被提出增加发育性口吃的神经风险。目的：了解非典型的前额叶和枕叶不对称是否在口吃的成年人中比流利的对照组更常见，并确定肺叶大小或不对称模式是否与口吃的严重程度或语言能力相关。方法：对16例持续性发展性口吃的成年人和16例匹配的对照组进行语言和口吃评估。受试者还进行了体积MRI扫描研究。测量整个半球、前额叶和枕叶区域，并按半球体积的比例计算体积。结果：两组之间的半球和总脑容量没有差异。对照组受试者的右前额叶体积大于左前额叶体积，左枕叶体积大于右枕叶体积。相比之下，口吃的成年人没有这些不对称。口吃的严重程度与特定的解剖结构无关，而口吃的成年人的语言处理缺陷与前额叶和枕叶体积减少有关。结论：发展性口吃与不典型的前额叶和枕叶不对称有关。此外，在口吃的成年人中，语言处理的缺陷与一些解剖测量有关。
Background: Two of the most consistent anatomic asymmetries found in the human brain are a larger right than left prefrontal and left than right occipital lobe. Reduced or reversed asymmetries of these regions are considered markers of atypical cerebral laterality, and atypical cerebral laterality has been proposed to increase neural risk for developmental stuttering. Objectives: To learn if atypical prefrontal and occipital lobe asymmetries are more common in adults who stutter vs fluent control subjects and to determine whether lobar size or asymmetry patterns are associated with stuttering severity or language abilities. Methods: Adults with persistent developmental stuttering (n=16) and matched control subjects (n=16) had language and stuttering assessments. Subjects were also studied with volumetric MRI scans. Total hemisphere, prefrontal, and occipital lobe regions were measured, and volumes were calculated proportionally to hemisphere volume. Results: Hemisphere and total brain volumes did not differ between the groups. Control subjects had the expected larger right than left prefrontal and larger left than right occipital lobe volume. In contrast, the adults who stutter did not have these asymmetries. Stuttering severity was not associated with specific anatomic configurations, whereas language-processing deficits in adults who stutter were associated with prefrontal and occipital volume reduction. Conclusions: Developmental stuttering is associated with atypical prefrontal and occipital lobe asymmetries. In addition, deficits in language processing were associated with some anatomic measures in the adults who stutter.