The minor histocompatibility antigen HA-1: A diallelic gene with a single amino acid polymorphism
The minor histocompatibility antigen HA-1: A diallelic gene with a single amino acid polymorphism
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DOI：
10.1126/science.279.5353.1054
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发表时间：
1998-02-13
期刊：
影响因子：
56.9
通讯作者：
Goulmy, E
中科院分区：
文献类型：
--
作者：
den Haan, JMM;Meadows, LM;Goulmy, E
次要组织相容性抗原（mHag）HA-1是唯一已知的mHag，其错配与人类白细胞抗原相同的骨髓移植后严重移植物抗宿主病（GVHD）的发生相关。发现HA-1是来源于KIAA 0223基因的等位基因的九肽。由KIAA 0223编码的HA-1阴性等位基因对应物与HA-1有一个氨基酸差异。HA-1等位基因特异性聚合酶链反应的家族分析表明，该等位基因多态性和HA-1表型之间存在确切的相关性。HA-1等位基因分型的供体和受体应改善供体的选择，并允许确定骨髓移植受体的HA-1诱导的GVHD发展的高风险。
The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GVHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1-negative allelic counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1-induced GVHD development.