Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery.
Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery.
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DOI：
10.1016/j.neuroscience.2012.02.030
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发表时间：
2012-05-03
期刊：
影响因子：
3.3
通讯作者：
Teixeira J
中科院分区：
文献类型：
--
作者：
Ochner CN;Stice E;Hutchins E;Afifi L;Geliebter A;Hirsch J;Teixeira J
减少与奖励有关的费用（例如，纹状体）神经激活。据推测，这些术后神经变化可能与记录的术后食物偏好变化有关;然而，这种关系以前尚未建立。在这项研究中，功能性磁共振成像和评级量表被用来评估神经反应，进食欲望（即，在Roux-en-Y胃旁路术（RYGB）手术前1个月和手术后1个月，14名女性对高热量和低热量食物线索的需求和喜好。评估所有变量的术前至术后RYGB变化，并将术后神经反应性变化与术后进食欲望和食物喜好变化进行回归。结果显示，术后中脑边缘显著减少（例如，纹状体）神经反应、进食欲望（想要）和喜欢高热量相对于低热量食物的线索。术后中脑边缘反应性的降低与术后对高热量食物和低热量食物的渴望（但不喜欢）的减少有关。有趣的是，食物需求的减少也与抑制性（例如，背外侧前额叶皮层）激活。结果与想要和喜欢之间的假设描述是一致的，支持这样的观点，即想要，但不喜欢，是通过多巴胺能奖励途径处理的。同时减少奖励相关的和抑制性激活预测减少的欲望吃可能表明，较少的饮食抑制引起抵抗潜在的过度消费，因为预期的高热量食物的奖励值下降后RYGB。
Reductions in reward-related (e.g., striatal) neural activation have been noted following obesity surgery. It has been speculated that these postoperative neural changes may be related to documented postoperative changes in food preferences; however, this relation has not been previously established. In this study, functional magnetic resonance imaging and rating scales were used to assess neural responsivity, desire to eat (i.e., wanting) and liking for high- and low- calorie food cues in 14 females 1 mo pre and 1 mo post Roux-en-Y gastric bypass (RYGB) surgery. Pre to post RYGB changes in all variables were assessed, and postoperative changes in neural responsivity were regressed on postoperative changes in desire to eat and liking of foods. Results revealed significant postoperative reductions in mesolimbic (e.g., striatal) neural responsivity, desire to eat (wanting) and liking for high- relative to low- calorie food cues. Postoperative reductions in mesolimbic responsivity were associated with postoperative reductions in wanting, but not liking, for high- vs. low- calorie foods. Interestingly, reductions in food wanting were also related to reductions in inhibitory (e.g., dorsolateral prefrontal cortex) activation following RYGB. Results are consistent with the hypothesized delineation between wanting and liking, supporting the notion that that wanting, but not liking, is processed through the dopaminergic reward pathway. Concurrent reductions in both reward-related and inhibitory activation predicted reductions in desire to eat might suggest that less dietary inhibition was elicited to resist potential overconsumption as the anticipated reward value of high-calorie foods decreased following RYGB.