Multi-elemental nanoparticle exposure after tantalum component failure in hip arthroplasty: In-depth analysis of a single case.
Multi-elemental nanoparticle exposure after tantalum component failure in hip arthroplasty: In-depth analysis of a single case.
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DOI：
10.1016/j.nano.2017.08.004
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发表时间：
2017-11
期刊：
影响因子：
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通讯作者：
J. Schoon;S. Geissler;J. Traeger;A. Luch;J. Tentschert;G. Perino;Frank Schulze;G. Duda;C. Perka;A. Rakow
中科院分区：
文献类型：
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作者：
J. Schoon;S. Geissler;J. Traeger;A. Luch;J. Tentschert;G. Perino;Frank Schulze;G. Duda;C. Perka;A. Rakow
多孔钽组件广泛用于髋关节翻修术中复杂的髋臼重建。钛-铝-钒或钴-铬-钼等多种其他金属合金主要用于人工关节装置。我们报告了一个钽组分失效的案例，这既是多金属暴露的原因，也是结果。我们的目标是评估和表征相关的颗粒物暴露和生物学后果。金属水平定量显示，在假体周围的隔室中，暴露于微粒和离解的钽、锆、铬、钴、钼、钛、铝和钒的物质大量存在。除了微米大小的颗粒外，还获得了大小范围和元素组成的纳米颗粒。组织学检查证实假体周围组织有一系列的坏死性改变。在目前的情况下，钽的释放伴随着来自其他使用的金属的颗粒。我们的结论是，对于金属毒性和相关风险的现实评估，总体上的活体暴露评估是强制性的。
Porous tantalum components are widely used for complex acetabular reconstructions in revision hip arthroplasty. Multiple other metal alloys such as titanium-aluminum-vanadium or cobalt-chromium-molybdenum are principally used in artificial joint setups. We report a case of tantalum component failure being both cause and effect of a multiple metal exposure. Our aims were to assess and to characterize associated particle exposure and biological consequences. Metal level quantification revealed substantialin vivoexposure to particulate and dissociated tantalum, zirconium, chromium, cobalt, molybdenum, titanium, aluminum and vanadium in periprosthetic compartments. Aside from micron-sized particles, nanoparticles of a broad size range and elemental composition were obtained. Histological exams verified a spectrum of necrotic changes in the periprosthetic tissues. In the presented case tantalum release was accompanied by concomitance of particles originating from other utilized metals. We conclude that an overallin vivoexposure assessment is mandatory for realistic appraisal of metal toxicity and associated risks.