Validity and Reliability of the Japanese Version of the Rome III Diagnostic Questionnaire for Irritable Bowel Syndrome and Functional Dyspepsia.
Validity and Reliability of the Japanese Version of the Rome III Diagnostic Questionnaire for Irritable Bowel Syndrome and Functional Dyspepsia.
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DOI：
10.5056/jnm15016
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发表时间：
2015-10-01
影响因子：
3.4
通讯作者：
Fukudo S
中科院分区：
文献类型：
--
作者：
Kanazawa M;Nakajima S;Oshima T;Whitehead WE;Sperber AD;Palsson OS;Drossman DA;Miwa H;Fukudo S
在日本，一直缺乏基于罗马III标准测量功能性胃肠道疾病存在的可靠诊断仪器。本研究的目的是翻译和验证在西方国家广泛使用的罗马III诊断问卷。原始版本的罗马III诊断问卷从英文翻译成日文，经过3次独立的正译、解析、反译和差异调和。从日本不同地区的三家医院招募了49例肠易激综合征（IBS）患者、32例功能性消化不良（FD）患者和56例无任何当前GI症状的受试者作为对照，并在14天内完成了两次IBS和FD诊断模块。Kappa统计用于评估重测信度。测试了用于区分IBS或FD患者与对照的每个诊断模块的灵敏度和特异性。翻译的IBS诊断模块和FD模块的中位Kappa统计量分别为0.63和0.68。IBS模块对医生诊断的敏感性、特异性和阳性预测值分别为61.2%、100%和100%，FD模块的敏感性、特异性和阳性预测值分别为53.2%、98.2%和94.4%。IBS患者便血发生率明显高于对照组（18.4% vs1.8%，P < 0.01）。日本版罗马III诊断问卷中的IBS和FD诊断模块有效且可靠。进一步的研究是必要的，以阐明红旗问卷的诊断效用。
Reliable diagnostic instruments for measuring the presence of functional gastrointestinal disorders based on the Rome III criteria have been lacking in Japan. The aims of the present study were to translate and validate the Rome III diagnostic questionnaire which was widely used in Western countries. The original version of Rome III diagnostic questionnaire was translated from English into Japanese through 3 independent forward translations, resolution, back translation and reconciliation of the differences. Forty-nine patients with irritable bowel syndrome (IBS), 32 patients with functional dyspepsia (FD) and 56 subjects without any current GI symptoms as controls were recruited from three hospitals located in different regions of Japan and completed the IBS and FD diagnostic modules twice within 14 days. Kappa statistic was used to assess test-retest reliability. The sensitivity and specificity of each diagnostic module for distinguishing IBS or FD patients from controls was tested. Median kappa statistics were 0.63 for the translated IBS diagnostic module and 0.68 for the FD module. The sensitivity, specificity, and positive predict value of the IBS module against physician diagnosis was 61.2%, 100%, and 100% and those of the FD module was 53.2%, 98.2%, and 94.4%, respectively. Meanwhile, IBS patients were significantly more likely to report blood in stools compared to controls (18.4% vs 1.8%, P < 0.01). The IBS and FD diagnostic modules on the Japanese version of the Rome III diagnostic questionnaire are valid and reliable. Further studies are warranted to elucidate the diagnostic utility of the red flag questionnaire.