An inverted U-shaped relationship between parathyroid hormone and body weight, body mass index, body fat
An inverted U-shaped relationship between parathyroid hormone and body weight, body mass index, body fat
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甲状旁腺激素与体重、体重指数、体脂呈倒U型关系
DOI：
10.1007/s12020-021-02635-y
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发表时间：
2021-02-06
期刊：
影响因子：
3.7
通讯作者：
Liu, Jian-Min
中科院分区：
文献类型：
--
作者：
Yuan, Tian-Jiao;Chen, Liu-Ping;Liu, Jian-Min
PurposeTo探讨甲状旁腺激素（PTH）水平与体重，体重指数（BMI），血脂谱和脂肪分布在原发性甲状旁腺功能亢进症（PHPT）和controls.MethodsThis是一个横断面研究，在192例PHPT和202对照。定量测定血清钙、25-羟基维生素D（25（OH）D）、PTH、血脂和其他激素的浓度。采用双能X线吸收法评估骨密度。另外66例PHPT患者和155例对照者采用定量CT进行脂肪分布评估。（P< 0.001），体重减轻（P< 0.001），BMI较低（P= 0.019），血清25（OH）D浓度降低（P< 0.001），总胆固醇（P= 0.036）、低密度脂蛋白胆固醇（P= 0.036）和较高的循环游离脂肪酸（FFA）浓度（P= 0.047）。校正混杂因素后，PTH与体重（r= 0.311，P < 0.001）、BMI（r= 0.268，P < 0.01）、内脏脂肪组织面积（r= 0.191，P < 0.05）在PTH的第一个三分位数中呈正相关。然而，在第二个三分位数中没有观察到这些关联。第三个三分位数PTH与体重呈负相关（r=-0.200，P < 0.05），BMI（r=-0.223，P < 0.05），与VAA无显著性差异与FFA呈正相关（r=-0.306，P = 0.065）（r= 0.230，P < 0.05）。结论PTH与体重、BMI、VAA呈倒U型关系，有助于解释这些参数之间相互矛盾的结果。并扩展我们对甲状旁腺素代谢作用的理解。
PurposeTo investigate the relationship between parathyroid hormone (PTH) levels and body weight, body mass index (BMI), lipid profiles, and fat distribution in subjects with primary hyperparathyroidism (PHPT) and controls.MethodsThis was a cross-sectional study in 192 patients with PHPT and 202 controls. Serum concentrations of calcium, 25-hydroxyvitamin D (25(OH)D), PTH, lipids profiles, and other hormones were quantified. Bone mineral density was assessed by dual-energy X-ray absorptiometry. Fat distribution evaluation utilizing quantitative computed tomography was conducted in another 66 patients with PHPT and 155 controls.ResultsPHPT patients were older (P< 0.001) and had less body weight (P< 0.001), lower BMI (P= 0.019), lower serum concentrations of 25(OH)D (P< 0.001), total cholesterol (P= 0.036), low-density lipoprotein-cholesterol (P= 0.036), and higher circulating concentration of free fatty acid (FFA) (P= 0.047) as compared with controls. After adjusting multiple confounders, PTH was positively correlated with weight (r= 0.311,P< 0.001), BMI (r= 0.268,P< 0.01), and visceral adipose tissue area (VAA) (r= 0.191,P< 0.05) in the first tertile of PTH. However, these associations were not observed in the second tertile. While in the third tertile, PTH was negatively correlated with weight (r= –0.200,P< 0.05), BMI (r= –0.223,P< 0.05) and marginally with VAA (r= –0.306,P= 0.065), it showed positive association with FFA (r= 0.230,P< 0.05).ConclusionsThe inverted U-shape relationship between PTH and body weight, BMI, VAA found in this study is helpful to explain the conflicting results among these parameters, and extend our understanding of the metabolic effects of PTH.