Cannabidiol treatment reduces the motivation to self-administer methamphetamine and methamphetamine-primed relapse in rats
Cannabidiol treatment reduces the motivation to self-administer methamphetamine and methamphetamine-primed relapse in rats
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DOI：
10.1177/0269881118799954
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发表时间：
2018-12-01
影响因子：
4.1
通讯作者：
Cornish, Jennifer L.
中科院分区：
文献类型：
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作者：
Hay, Gracie L.;Baracz, Sarah J.;Cornish, Jennifer L.
背景：甲基苯丙胺是一种成瘾性兴奋剂，可引起许多不良的生理、心理和心理社会影响。初步证据表明，大麻二酚，一种大麻植物的非醉人成分，可能在治疗阿片类药物和尼古丁依赖方面有效。然而，还没有研究检查大麻二醇治疗是否会对甲基苯丙胺成瘾产生影响。目的：本研究调查了大麻二醇的使用是否降低了自我使用甲基苯丙胺的动机，并在戒断后再次出现寻找甲基苯丙胺的行为。方法：32只植入颈静脉导管的雄性SD大鼠，最初接受训练，通过杠杆按压给药，按照固定比例1的强化程序进行2小时的训练。实验1中的大鼠(n=16)随后进入递增比率强化程序，以检查大麻二醇(0、20、40和80 mg/kg)对自身给药甲基苯丙胺的动机的影响。实验2(n=16)的大鼠在灭绝后测试大麻二醇对甲基苯丙胺刺激的恢复的影响。结果：大麻二醇(80 mg/kg，而不是40 mg/kg或20 mg/kg)降低了小鼠自我给药的动机，减少了甲基苯丙胺激发后对甲基苯丙胺寻找行为的复发。结论：首次证明大麻二醇可降低寻找和消费甲基苯丙胺的动机，提示大麻二醇可能是一种治疗甲基苯丙胺依赖的新药物。
Background: Methamphetamine is an addictive stimulant that can cause many adverse physical, psychological and psychosocial effects. Preliminary evidence shows cannabidiol, a non-intoxicating constituent of the cannabis plant, may have efficacy in treating opioid and nicotine dependence. However, no study has yet examined whether cannabidiol treatment might impact on methamphetamine addiction. Aims: The current study investigated whether cannabidiol administration reduces the motivation to self-administer methamphetamine and relapse to methamphetamine-seeking behavior following abstinence. Methods: Thirty-two male Sprague Dawley rats with implanted jugular vein catheters were initially trained to self-administer methamphetamine via lever press during two-hour sessions on a fixed ratio 1 schedule of reinforcement. Rats in experiment 1 (n=16) then advanced to a progressive ratio reinforcement schedule to examine the effects of cannabidiol (0, 20, 40, and 80 mg/kg intraperitoneal) on motivation to self-administer methamphetamine. Rats in experiment 2 (n=16) were tested for cannabidiol effects on methamphetamine-primed reinstatement following extinction. Results: Cannabidiol (80 mg/kg, but not 40 mg/kg, or 20 mg/kg) reduced the motivation to self-administer methamphetamine and attenuated methamphetamine-primed relapse to methamphetamine-seeking behavior after extinction. Conclusion: This is the first demonstration that cannabidiol can reduce the motivation to seek and consume methamphetamine, and suggests that cannabidiol might be worth trialing as a novel pharmacotherapy for methamphetamine dependence.